Application of alanine dosimetry in dose assessment for ocular melanoma patients undergoing proton radiotherapy – preliminary results

• Authors: Gabriela Mierzwińska , Magdalena Kłodowska , Barbara Michalec , Anna Pędracka , Marzena Rydygier , Jan Swakoń , Michael P. R. Waligórski
• Languages of publication: EN

Abstracts

EN

Basing on alanine solid state/electron paramagnetic resonance (EPR) dosimetry, a supplementary method of cumulatively recording the therapeutic dose received by ocular cancer patients undergoing fractionated proton radiotherapy is proposed. By applying alanine dosimetry during the delivery of consecutive fractions, the dose received within each fraction can be read out by EPR spectrometry and a final permanent cumulative record of the total dose delivered obtained. The dose response of the alanine detector was found to be practically independent on its position within the extended proton Bragg peak region. Dose measurements based on entrance dose recorded in proton beams individually formed for each patient are presented. The described method will be applied as a complementary Quality Assurance procedure for patients undergoing proton radiotherapy at the Institute of Nuclear Physics, Polish Academy of Sciences, Krakow, Poland (IFJ PAN).

Keywords

EN

alanine · EPR dosimetry · proton beam · proton radiotherapy · Quality Assurance (QA)

• Publisher: De Gruyter Open
• Journal: Nukleonika
• Year: 2015
• Volume: 60
• Issue: 3
• Pages: 609-613

Dates

published

1 - 9 - 2015

accepted

20 - 5 - 2015

online

25 - 9 - 2015

received

29 - 9 - 2014

Contributors

author

Gabriela Mierzwińska

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

author

Magdalena Kłodowska

• Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone]

author

Barbara Michalec

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

author

Anna Pędracka

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

author

Marzena Rydygier

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

author

Jan Swakoń

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland, Tel.: [phone], Fax: [phone]

author

Michael P. R. Waligórski

• The Henryk Niewodniczański Institute of Nuclear Physics of the Polish Academy of Sciences, 152 Radzikowskiego Str., 31-342 Krakow, Poland and Centre of Oncology, Maria Skłodowska-Curie Memorial Institute, Krakow Branch, 11 Garncarska Str., 31-115 Krakow, Poland

References

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• 3. Schauer, D. A., Iwasaki, A., Romanyukha, A. A., Swartz, H. M., & Onori, S. (2006). Electron paramagnetic resonance (EPR) in medical dosimetry. Radiat. Meas., 41(Suppl.), S117-S123.[Crossref]
• 4. Michalec, B., Mierzwińska, G., Sowa, U., Ptaszkiewicz, M., Nowak, T., & Swakoń, J. (2012). Alanine dosimetry of 60 MeV proton beam - preliminary results. Nukleonika, 57, 503-506.
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• 6. International Standard ISO/WD 15566.1. (1998). Practice for use of alanine-EPR dosimetry system (1998). International Organization of Standardization.
• 7. Michalec, B., Swakon, J., Sowa, U., Ptaszkiewicz, M., Cywicka-Jakiel, T., & Olko, P. (2010). Proton radiotherapy facility for ocular tumours at the IFJ PAN in Krakow, Poland. Appl. Radiat. Isot., 68, 738-742.[Crossref][WoS]
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Identifiers

DOI

10.1515/nuka-2015-0109