Purine nucleoside analogs in the therapy of cancer
and neuroinflammation

• Authors: Danijela Savić , Tijana Stanković , Irena Lavrnja , Ana Podolski-Renić , Jasna Banković , Sanja Peković , Mirjana Stojiljković , Ljubisav Rakić , Sabera Ruždijić , Milica Pešić
• Languages of publication: EN

Abstracts

EN

Purine nucleoside analogs have been in clinical
use for almost 50 years. At the beginning developed as
antiviral agents, later their efficacy was demonstrated in
cancer treatment, especially hematological malignances.
The approval of new purine nucleoside analogs by US
Food and Drug Administration (FDA) over the past decade
implies that the interest for these drugs still exists. Here,
we review new nucleoside analogs that are currently in
preclinical or clinical development as anticancer agents. In
addition, we highlight the potential for implementation of
these drugs in other pathological conditions, particularly
in neuroinflammation.

Keywords

EN

purine nucleoside analogs; cancer; neuroinflammation; brain injury

• Publisher: De Gruyter Open
• Journal: Molecular inhibitors in targeted therapy
• Year: 2015
• Volume: 1
• Issue: 1

Dates

accepted

11 - 5 - 2015

received

27 - 3 - 2015

online

4 - 6 - 2015

Contributors

author

Danijela Savić

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Tijana Stanković

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Irena Lavrnja

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Ana Podolski-Renić

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Jasna Banković

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Sanja Peković

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Mirjana Stojiljković

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Ljubisav Rakić

• Serbian Academy of Sciences and Arts, KnezMihailova
  35, Belgrade, Serbia

author

Sabera Ruždijić

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

author

Milica Pešić

• Institute for Biological
  Research, Department of Neurobiology, University of
  Belgrade,BulevarDespotaStefana 142, Belgrade, Serbia

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Identifiers

DOI

10.1515/motth-2015-0002