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2014 | 10 | 1 |
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A case of Multiple Unilateral Pulmonary arteriovenous Malformation Relapse: Efficacy of embolization treatment

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Pulmonary arteriovenous Malformations (PAVMs) are a rare vascular alteration characterized by abnormal communications between the pulmonary arteries and veins resulting in an extracardiac right-to-left (R-L) shunt. The majority of PAVMs are associated with an autosomal dominant vascular disorder also known as Osler-Weber- Rendu Syndrome. PAVMs appearance can be both single and multiple. Clinical manifestations include hypoxemia, dyspnea cyanosis, hemoptysis and cerebrovascular ischemic events or abscesses. We report a case of an 18 year old female with severe respiratory failure caused by a relapse of multiple unilateral pulmonary arterovenous fistula. Symptoms at admission include dyspnea, cyanosis and clubbing. The patient underwent pulmonary angio-TC scan, brain CT and echocardiography. The thoracic angio-CT scan showed the presence of PAVMs of RUL and RLL; a marked increase of right bronchial artery caliber and its branches with an aneurismatic dilatation was also observed. The patient underwent percutaneous transcatheter embolization using Amplatzer Vascular Plug IV; a relevant clinical and functional improvement was subsequently recorded. Embolization is effective in the treatment of relapsing PAVMS.
Physical description
1 - 1 - 2015
17 - 12 - 2015
26 - 10 - 2015
4 - 11 - 2015
  • [1] Cartin-Ceba R, Swanson KL, Krowka MJ. Pulmonary arteriovenous malformations Chest 2013 Sep;144(3):1033-44.[WoS][Crossref]
  • [2] Bayrak-Toydemir P, Mao R, Lewin S, Mc Donald J. Hereditary hemorrhagic teleangectasia: an overview of diagnosis and management in the molecular era for clinicians. Genet Med 2004; 6:175-91[Crossref]
  • [3] Shovlin CL. Pulmonary arteriovenous malformations. Am J Respir Crit Care Med. 2014 Dec 1;190(11):1217-28.[WoS]
  • [4] Mazzarella G, Iadevaia C, Guerra G, Rocca A, Corcione N, Rossi G et al.: Intralobar pulmonary sequestration in an adult female patient mimicking asthma: a case report. Int J Surg. 2014; 12(Suppl 2):S73-7.[Crossref][WoS]
  • [5] Cattaneo F, Guerra G, Parisi M, Lucariello A, De Luca A, De Rosa N et al.: Expression of Formyl-peptide Receptors in Human Lung Carcinoma. Anticancer Res. 2015 May;35(5):2769-74.
  • [6] Corbi G, Bianco A, Turchiarelli V, Cellurale M, Fatica F, Daniele A et al.: Potential Mechanisms Linking Atherosclerosis and Increased Cardiovascular Risk in COPD: Focus On Sirtuins. Int J Mol Sci. 2013 Jun 17;14(6):12696-713.[Crossref][WoS]
  • [7] Cattaneo F, Guerra G, Parisi M, De Marinis M, Tafuri D, Cinelli M et al.: Cell-surface receptors transactivation mediated by g protein-coupled receptors. Int J Mol Sci. 2014 Oct 29;15(11):19700-28.[WoS][Crossref]
  • [8] Mazzarella G, Bianco A, Catena E, De Palma R, Abbate GF. Th1/Th2 lymphocyte polarization in asthma, Allergy 2000; 55(Suppl. 61):6-9.[Crossref]
  • [9] Esposito V, Lucariello A, Savarese L, Cinelli MP, Ferraraccio F, Bianco A et al.: Morphology changes in human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM₁.₀) and pollen allergens. Environ Pollut. 2012 Dec;171:162-7.[WoS]
  • [10] Mazzarella G, Esposito V, Bianco A, Ferraraccio F, Prati MV, Lucariello A et al.: Inflammatory effects on human lung epithelial cells after exposure to diesel exhaust micron sub particles (PM₁.₀) and pollen allergens. Environ Pollut. 2012 Feb;161:64-9[WoS]
  • [11] Mazzarella G, Lucariello A, Bianco A, Calabrese C, Thanassoulas T, Savarese L et al.: Exposure to submicron particles (PM1.0) from diesel exhaust and pollen allergens of human lung epithelial cells induces morphological changes of mitochondria tonifilaments and rough endoplasmic reticulum. In Vivo. 2014 Jul-Aug;28(4):557-61.
  • [12] Mazzarella G, Ferraraccio F, Prati MV, Annunziata S, Bianco A, Mezzogiorno A et al.: Effects of diesel exhaust particles on human lung epithelial cells: an in vitro study. Respir Med. 2007 Jun;101(6):1155-62.[Crossref][WoS]
  • [13] Grella E, Paciocco G, Caterino U, Mazzarella G. Respiratory function and atmospheric pollution. Monaldi Arch Chest Dis. 2002 Jun-Aug;57(3-4):196-9.
  • [14] de Laurentis G, Paris D, Melck D, Montuschi P, Maniscalco M, Bianco A et al.: Separating Smoking-Related Diseases Using NMR-Based Metabolomics of Exhaled Breath Condensate. J Proteome Res. 2013 Mar 1;12(3):1502-11.[Crossref][WoS]
  • [15] Vatrella A, Montagnani S, Calabrese C, Parrella R, Pelaia G, Biscione GL et al.: Neuropeptide expression in the airways of COPD patients and smokers with normal lung function. J Biol Reg Homeos Ag 2010 Oct-Dec;24(4):425-32.
  • [16] Moccia F, Dragoni S, Cinelli M, Montagnani S, Amato B, Rosti V et al.: How to utilize Ca2+ signals to rejuvenate the repairative phenotype of senescent endothelial progenitor cells in elderly patients affected by cardiovascular diseases: a useful therapeutic support of surgical approach? BMC Surg 2013 Oct 8;13(Suppl 2):S46.[WoS]
  • [17] Moccia F, Guerra G. Ca2+ Signalling in Endothelial Progenitor Cells: Friend or Foe? J Cell Physiol. 2015 Aug 6. doi: 10.1002/ jcp.25126. [Epub ahead of print][Crossref]
  • [18] White RI Jr, Pollak JS, Wirth JA. Pulmonary arteriovenous malformations: diagnosis and transcatheter embolotherapy. J Vasc Interv Radiol 1996; 7: 787-804.[Crossref]
  • [19] Faughnan ME, Lui YW, Wirth JA, Pugash RA, Redelmeier DA, Hyland RH et al.: Diffuse pulmonary arteriovenous malformations: characteristics and prognosis. Chest 2000; 117: 31-38.
  • [20] Brunese L, Greco B, Setola FR, Lassandro F, Guarracino MR, De Rimini M et al.: Non-small cell lung cancer evaluated with quantitative contrast-enhanced CT and PET-CT: net enhancement and standardized uptake values are related to tumour size and histology. Med Sci Monit. 2013 Feb 7;19:95-101.[Crossref]
  • [21] Gupta P, Mordin C, Curtis J, Hughes JM, Shovlin CL, Jackson JE. Pulmonary arteriovenous malformations: effect of embolization on right-to-left shunt, hypoxemia, and exercise tolerance in 66 patients. Am JRoentgenol 2002; 179: 347-355.
  • [22] Faughnan ME, Palda VA, Garcia-Tsao G et al. International guidelines for the diagnosis and man-agement of hereditary hemorrhagic telangiectasia. J Med Genet 2011; 48: 73-87.
  • [23] Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC et al.: The -403 G-->A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes Immun. 2000 Dec;1(8):509-14.[Crossref]
  • [24] Spiteri MA, Bianco A, Strange RC, Fryer AA. Polymorphisms at the glutathione S-transferase, GSTP1 locus: a novel mechanism for susceptibility and development of atopic airway inflammation, Allergy 2000; 55(Suppl. 61):15-20.[Crossref]
  • [25] Fryer AA, Bianco A, Hepple M, Jones PW, Strange RC, Spiteri MA. Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma. Am J Respir Crit Care Med. 2000 May;161(5):1437-42.
  • [26] Bianco A, Mazzarella G, Turchiarelli V, Nigro E, Corbi G, Scudiero O et al.: Adiponectin: an attractive marker for metabolic disorders in Chronic Obstructive Pulmonary Disease (COPD). Nutrients. 2013 Oct 14;5(10):4115-25.[Crossref]
  • [27] Nigro E, Scudiero O, Monaco ML, Palmieri A, Mazzarella G, Costagliola C et al.: New insight into adiponectin role in obesity and obesity-related diseases. Biomed Res Int. 2014;2014:658913.[WoS]
  • [28] Daniele A, De Rosa A, Nigro E, Scudiero O, Capasso M, Masullo M et al.: Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. Int J Biochem Cell Biol. 2012 Mar;44(3):563-9.[WoS][Crossref]
  • [29] Nigro E, Scudiero O, Sarnataro D, Mazzarella G, Sofia M, Bianco A et al.: Adiponectin affects lung epithelial A549 cell viability counteracting TNFα and IL-1s toxicity through AdipoR1. Int J Biochem Cell Biol. 2013 Jun;45(6):1145-53.[Crossref]
  • [30] Nigro E, Imperlini E, Scudiero O, Monaco ML, Polito R, Mazzarella G et al.: Differentially expressed and activated proteins associated with non small cell lung cancer tissues. Respir Res. 2015 Jun 24;16:74.[WoS]
  • [31] Nigro E, Daniele A, Scudiero O, Ludovica Monaco M, Roviezzo F, D’Agostino B et al.: Adiponectin in asthma: implications for phenotyping. Curr Protein Pept Sci. 2015;16(3):182-7.
  • [32] Berra-Romani R, Avelino-Cruz JE, Raqeeb A, Della Corte A, Cinelli M, Montagnani S et al.: Ca2+-dependent nitric oxide release in the injured endothelium of excised rat aorta: a promising mechanism applying in vascular prosthetic devices in aging patients. BMC Surg 2013 Oct 8;13(Suppl 2):S40.[WoS]
  • [33] Moccia F, Lodola F, Dragoni S, Bonetti E, Bottino C, Guerra G et al.: Ca2+ signalling in endothelial progenitor cells: a novel means to improve cell-based therapy and impair tumour vascularisation. Curr Vasc Pharmacol. 2014 Jan;12(1):87-105.[WoS][Crossref]
  • [34] Dragoni S, Laforenza U, Bonetti E, Reforgiato M, Poletto V, Lodola F et al.: Enhanced Expression of Stim, Orai, and TRPC Transcripts and Proteins in Endothelial Progenitor Cells Isolated from Patients with Primary Myelofibrosis. PLoS One 2014 Mar 6;9(3):e91099
  • [35] Moccia F, Dragoni S, Lodola F, Bonetti E, Bottino C, Guerra G et al.: Store-dependent Ca2+ entry in endothelial progenitor cells as a perspective tool to enhance cell-based therapy and adverse tumour vascularisation. Curr Med Chem 2012 Dec 1;19(34):5802-18.[Crossref]
  • [36] Piantedosi FV, Caputo F, Mazzarella G, Gilli M, Pontillo A, D’Agostino D et al.: Gemcitabine, ifosfamide and paclitaxel in advanced/metastatic non-small cell lung cancer patients: a phase II study. Cancer Chemother Pharmacol. 2008 Apr;61(5):803-7.[WoS][Crossref]
  • [37] Comella P, Frasci G, De Cataldis G, Panza N, Cioffi R, Curcio C et al.: Cisplatin/carboplatin + etoposide + vinorelbine in advanced non-small-cell lung cancer: a multicentre randomised trial. Gruppo Oncologico Campano. Br J Cancer. 1996 Dec;74(11):1805-11[Crossref]
  • [38] Nigro E, Imperlini E, Scudiero O, Monaco ML, Polito R, Mazzarella G et al.: Differentially expressed and activated proteins associated with non small cell lung cancer tissues. Respir Res. 2015 Jun 24;16:74[WoS]
  • [39] Moccia F, Zuccolo E, Poletto V, Cinelli M, Bonetti E, Guerra G et al.: Endothelial progenitor cells support tumour growth and metastatisation: implications for the resistance to antiangiogenic therapy. Tumour Biol. 2015 Aug 2. [Epub ahead of print][Crossref]
  • [40] Dragoni S, Reforgiato M, Zuccolo E, Poletto V, Lodola F, Ruffinatti FA et al.: Dysregulation of VEGF-induced proangiogenic Ca2+ oscillations in primary myelofibrosis-derived endothelial colony forming cells. Exp Hematol. 2015 Sep 30. pii: S0301-472X(15)00663-3.
  • [41] Lee DW, White RI Jr, Egglin TK, Pollak JS, Fayad PB, Wirth JA et al.: Embolotherapy of large pulmonary arteriovenous malformations: long-term results. Ann Thorac Surg. 1997 Oct;64(4):930-9; discussion 939-40.[Crossref]
  • [42] Chilvers ER, Whyte MK, Jackson JE, Allison DJ, Hughes JM. Effect of percutaneous transcatheter embolization on pulmonary function, right-to-left shunt, and arterial oxygenation in patients with pulmonary arteriovenous malformations. Am Rev Respir Dis. 1990;142(2):420-425.
  • [43] Pollak JS, Saluja S, Thabet A, Henderson KJ, Denbow N, White RI Jr. Clinical and anatomic outcomes after embolotherapy of pulmonary arteriovenous malformations. J Vasc Interv Radiol. 2006;17(1):35-44.[Crossref]
  • [44] Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML. Embolisation therapy for pulmonary arteriovenous malformations. Cochrane Database Syst Rev. 2015 Jan 29;1:CD008017 [WoS]
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