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2014 | 10 | 1 |

Article title

Our experience of liver Epithelioid
Hemangioendothelioma: from a misdiagnosis to
liver transplantation with long term follow-up


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Malignant Hepatic Epithelioid hemangioendothelioma
(HEHE) is an uncommon vascular tumor of intermediate
malignant potential. HEHE is a rare tumor and it
is difficult to diagnose for surgeons, hepatologists, radiologists
and pathologists. So, misdiagnosis with a delay
of the treatment is not uncommon.
We describe a case of a young woman with a diagnosis of
HEHE made 6 years after the first evidence of liver mass
with a very long term follow-up after surgical treatment.
She had two diagnoses of Hepatocellurar carcinoma (HCC)
and a diagnosis of Cholangiocarcinoma after three different
fine needle biopsies. After clinical observation, a new
laparoscopic core biopsy was performed. In a first time
approach, considering clinical and radiological patterns,
a diagnosis of Budd-Chiari Syndrome was finally made.
For that the patient underwent an orthotopicliver transplantation
The surgical sample histological analysis allowed a definitive
diagnosis of HEHE. At last, at follow up 7 years after three OLTx the patient
is still alive and in good health with no evidence of








Physical description


2 - 11 - 2015
21 - 12 - 2015
23 - 10 - 2015


  • Unit of Hepatobiliary Surgery and Liver Transplant Center,
    Department of Gastroenterology and Transplantation,”A. Cardarelli”
    Hospital, Naples, Italy
  • Department of Clinical Medicine and Surgery, University
    of Naples Federico II, Italy
  • Department of Pathology, A. Cardarelli
    Hospital, Naples, Italy
  • Department of Sport Sciences and Wellness, University
    of Naples “Parthenope”, Naples, Italy
  • Unit of Hepatobiliary Surgery and Liver Transplant Center,
    Department of Gastroenterology and Transplantation,”A. Cardarelli”
    Hospital, Naples, Italy
  • Unit of Hepatobiliary Surgery and Liver Transplant Center,
    Department of Gastroenterology and Transplantation,”A. Cardarelli”
    Hospital, Naples, Italy
  • Unit of Hepatobiliary Surgery and Liver Transplant Center,
    Department of Gastroenterology and Transplantation,”A. Cardarelli”
    Hospital, Naples, Italy
  • Unit of Hepatobiliary Surgery and Liver Transplant Center,
    Department of Gastroenterology and Transplantation,”A. Cardarelli”
    Hospital, Naples, Italy


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