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Journal

2014 | 10 | 1 |

Article title

Assessment of the feasibility of TACE combined with intratumoral injection of cisplatin in hepatocellular carcinoma

Content

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Languages of publication

EN

Abstracts

EN
The feasibility of transcatheter arterial chemoembolization (TACE) combined with intratumoral injection of cisplatin as treatment for hepatocellular carcinoma. 30 cases receiving TACE were denoted the TACE group, another 30 cases receiving TACE combined with an intratumoral multi-point injection of cisplatin were denoted the TACE/cisplatin group. Cases with partial remission/complete remission (PR/CR) were analyzed using 2 tests; alpha fetoprotein (AFP), aspartate amino transferase (AST), total bilirubin (TBIL), erythrocyte, and platelet levels were detected and the differences between two groups were analyzed using the Student’s t-test; cases with complications, including intrahepatic metastasis (IM), upper gastrointestinal bleeding (UGB), and liver failure were also counted. The correlation of clinical parameters with PR/CR was analyzed using multifactorial correlation analysis. Cases with PR/CR in the TACE/cisplatin group were significantly more than in TACE group, accompanied by significant declination in FAP. There were no significant differences of AST, ALT, TBIL, blood urea nitrogen (BUN), white blood cells (WBC), red blood cells (RBC), and platelets (PLT) between two groups; 3 cases with IM, one case with UGB and one case with LF were found in the TACE group, but only 1 case with IM was found in the TACE/cisplatin group. In addition, tumor stage was correlated with PR/CR. We concluded that TACE combined with intratumoral injection of cisplatin was more effective than TACE, and with fewer complications and side effects.

Publisher

Journal

Year

Volume

10

Issue

1

Physical description

Dates

published
1 - 1 - 2015
received
10 - 7 - 2015
online
17 - 12 - 2015
accepted
30 - 9 - 2015

Contributors

author
  • Third Hospital of Qinhuangdao city, China
author
  • Third Hospital of Qinhuangdao city, China
author
  • Third Hospital of Qinhuangdao city, China
author
  • The Shandong province Zibo City Qidu hospital, Qinhuangdao City Third Hospital Road, Haigang district the founding of Hebei city of Qinhuangdao province No. 222, zip code 066000 China, Tel; 15864477727
author
  • Third Hospital of Qinhuangdao city, China
author
  • Third Hospital of Qinhuangdao city, China
author
  • Third Hospital of Qinhuangdao city, China

References

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  • [2] Xie Z.B., Wang X.B., Chen J., et al., Letter: Is DEB-TACE associated with better tumor response than cTACE in meta-analysis? authors’ reply, Hepatology research, the official journal of the Japan Society of Hepatology, 2015
  • [3] El-Halawany M.S., Ismail H.M., Zeeneldin A.A., et al., Investigating the pretreatment miRNA expression patterns of advanced hepatocellular carcinoma patients in association with response to TACE treatment, BioMed research international, 2015, 649-750
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  • [13] Wang Y., Liu Y., Liu Y., et al., A polymeric prodrug of cisplatin based on pullulan for the targeted therapy against hepato cellular carcinoma, International journal of pharmaceutics, 2015, 483(1-2), 89-100
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_med-2015-0075
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