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2014 | 10 | 1 |
Article title

Trends in the treatment of risk factors for stroke in a Czech stroke unit

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The goal of this study is to evaluate therapeutic
trends for several diseases that represent risk factors for
stroke. The relative frequency of therapy with compounds
that influence the risk factors for stroke was monitored
in a group of 3,290 patients who were hospitalised in the
Stroke Unit at the University Hospital in Hradec Kralove
between 2005 and 2012. For most drugs monitored, the
reasons for the significant decrease or increase in use were
causes other than the reduction of stroke risk. Despite this
finding, the majority of statistically significant changes
had, according to review of comparative studies, a posi-
tive effect on prevention of stroke. Motivation to change
treatment of stroke risk factors, such as hypertension,
diabetes mellitus and hypercholesterolemia, was mainly
aimed at sufficient disease management with a minimum
of adverse effects. On the other hand, optimization of
stroke recurrence and economic factors were motivations
to treatment changes in prevention with antiplatelets.
Antidiabetics were associated with an increase in met-
formin use and reduction in insulin use. For antihyperten-
sives, the most significant reduction was associated with
the use of diuretics, although calcium channel blockers
and beta-blockers are also less used. Additionally, the use
of the ACE inhibitor ramipril increased
Physical description
26 - 10 - 2015
29 - 9 - 2015
4 - 9 - 2013
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