Efficacy of mistletoe for chemical pleurodesis in
rats without malignancy

• Authors: Hyo Yeong Ahn , Jeong Su Cho , Yeong Dae Kim , Hoseok I , Yeon Ji Kim , Ahrong Kim , Chang Hun Lee
• Languages of publication: EN

Abstracts

EN

Chemical pleurodesis is an effective treatment
modality to reduce recurrence of malignant effusion.
Several agents have been used in chemical pleurodesis
but, it is not yet clear which is better. Eighteen Sprague-
Dawley rats were used and classified into three groups:
a group intrapleurally injected normal saline (group A,
n=6), 400mg/kg talc (group B, n=6), and 9mg/kg mistletoe
extraction (ME) (group C, n=6). Autopsy was performed to
evaluate the pleural adhesion, pathologic examination of
pleura and lung and bronchoalveolar lavage fluid analysis
4 weeks after pleurodesis. Both group B and C showed an
obvious pleural adhesion and there was no significant difference
in grade of pleural adhesion between two groups
(p=0.58). The parietal pleural thickness in talc group than
ME group was significantly thicker (p=0.002) and the visceral
pleura of talc group showed marked foreign body
reaction with fibrosis and many multinucleated giant
cells associated with talc crystal. This study suggests that
pleurodesis using ME in condition without malignancy
has comparable effect to pleurodesis using talc. However,
additional experimental study in large animal or clinical trials would be required to prove a safety and an efficacy
of pleurodesis using ME.

Keywords

EN

chemical pleurodesis; mistletoe extraction; animals

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

accepted

13 - 8 - 2015

online

4 - 9 - 2015

received

9 - 2 - 2015

Contributors

author

Hyo Yeong Ahn

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

author

Jeong Su Cho

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

author

Yeong Dae Kim

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

author

Hoseok I

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

author

Yeon Ji Kim

• Department of Thoracic and Cardiovascular Surgery,
  Pusan National University Yangsan Hospital, Yangsan, Republic of
  Korea

author

Ahrong Kim

• Department
  of Thoracic and Cardiovascular Surgery, Pusan National University
  Hospital, Biomedical Research Institution, Busan, Republic
  of Korea

author

Chang Hun Lee

• Department of Pathology, Pusan National
  University Hospital, Biomedical Research Institution, Busan,
  Republic of Korea

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Identifiers

DOI

10.1515/med-2015-0051