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Journal
2014 | 10 | 1 |
Article title

The impact of Tegillarca granosa extract
haishengsu on HL-60 cell

Content
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EN
Abstracts
EN
Haishengsu (Hss) is a purified protein from
Tegillarca granosa that has been used as a traditional
Chinese medicine to treat cancer for more than a century.
In this study, we observed the impact of Haishengsu (Hss)
on the proliferation and differentiation of HL-60 cells in
the leukemic cell line by taking tretinoin and AS2O3 as
a positive control and making a comparative analysis
between the effect of Hss and tretinoin and AS2O3. We
found that Hss could significantly inhibit the proliferation
of HL-60 cells and caused most of the cells to stay in
the G0/G1 phase. Its effect was much stronger than that of
tretinoin and AS2O3, and the ability of Hss to induce differentiation
was close to tretinoin. Hss functions probably
by inhibiting the expression of the Bcl-2 and MPO genes
and further promoting the expression of the Bax gene. Hss
has a significant effect on both inhibiting the proliferation
and inducing the differentiation of HL-60 cells. It is possible
that Hss may be a new kind of clinical differentiation
inducer.
Publisher
Journal
Year
Volume
10
Issue
1
Physical description
Dates
accepted
25 - 5 - 2015
online
3 - 8 - 2015
received
6 - 4 - 2015
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_med-2015-0048
Identifiers
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