Differences of plasma IL-1 and TNF-α in healthy
Chinese Population

• Authors: Jintao Yuan , Lan Wang , Yijin Lin , Jianhong Chen , Jianghong Hu
• Languages of publication: EN

Abstracts

EN

Ple iotropic proinflammatory cytokines, interleukin-
1 (IL-1) and tumor necrosis factor-α (TNF-α), involved
in the regulations of various immune responses, inflammatory
processes and hematopoiesis. In the present study,
the expression levels of IL-1 and TNF-α were detected by
enzyme-linked immunosorbent assay (ELISA). Following
the cytokine blockade as a successful clinical therapy for
autoimm une diseases such as rheumatoid arthritis, the
patients are more susceptible to a variety of opportunistic
infections. IL-1 and TNF-α may be useful predictive biomarkers
of diseases and offer potential targets for therapeutic
intervention of inflammatory diseases. However,
our results showed that the plasma IL-1 level was significantly
higher in women compared to men (69.5 ± 19.8 pg/
ml in men and 80.1 ± 19.5 pg/ml in women, respectively);
the plasma levels of TNF-α were higher in men than
women (20.8 ± 4.9 pg/ml and 18.7 ± 7.1 pg/ml, respectively).
The significant gender difference of plasma interleukin-1
(IL-1) and TNF-α levels present in healthy adults in Jiangsu
Province, China (P=0.002 and P=0.015, respectively), and
may be as a hint for sex differences of susceptibility to
many diseases and elementary immune response.

Keywords

EN

Proinflammatory cytokine; IL-1; TNF-α; genderdifference

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

accepted

13 - 5 - 2015

received

4 - 5 - 2014

online

9 - 6 - 2015

Contributors

author

Jintao Yuan

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

author

Lan Wang

• Danyang Blood Center of Jiangsu Province, Danyang, Jiangsu 212300, China

author

Yijin Lin

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

author

Jianhong Chen

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

author

Jianghong Hu

• Danyang People’s Hospital of Jiangsu Province, 2 Xinmin West Road, Danyang, 212300, China
• Danyang affiliated Hospital with Nantong University, Danyang, Jiangsu 212300, China

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Identifiers

DOI

10.1515/med-2015-0044