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2014 | 10 | 1 |

Article title

The latent cytomegalovirus decreases telomere
length by microcompetition


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Reduced telomere length has been associated
with aging and age-related diseases. Latent infection with
the Cytomegalovirus (CMV) induces telomere shortening
in the infected cells. Latent CMV infection may cause
reduced telomere length via GABP transcription factor
deficiency, according to the Microcompetition Theory.
Microcompetition and viral-induced transcription factor
deficiency is important since most people harbor a latent
viral infection.








Physical description


26 - 4 - 2015
27 - 5 - 2015
30 - 4 - 2015


  • The Center for the Biology of Chronic Disease
    (CBCD), Valley Cottage, NY 10989, USA
  • The Center for the Biology of Chronic Disease
    (CBCD), Valley Cottage, NY 10989, USA


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  • [2] van de Berg P.J., Griffiths S.J., Yong S.L., Macaulay R.,Bemelman F.J., Jackson S. et al., Cytomegalovirus InfectionReduces Telomere Length of the Circulating T Cell Pool, J.Immunol. 2010, 184, 3417-3423[WoS]
  • [3] Polansky H., Microcompetition with Foreign DNA and the Originof Chronic Disease., The Center for the Biology of ChronicDisease, New York, 2003
  • [4] Liu B.H., Wang X., Ma Y.X., Wang S., CMV Enhancer/HumanPDGF-Beta Promoter for Neuron-Specific Transgene Expression,Gene Ther., 2004, 11(1), 52-60[Crossref]
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  • [7] Yu S., Cui K., Jothi R., Zhao D.M., Jing X., Zhao K. et al., GABPcontrols a critical transcription regulatory module that isessential for maintenance and differentiation of hematopoieticstem/progenitor cells, Blood, 2011, 117(7), 2166-2178[WoS]
  • [8] Sarek G., Vannier J.B., Panier S., Petrini J.H.J., Boulton S.J.,TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-LoopUnwinding, Molecular Cell, 2015, 57(4), 622-635[Crossref]
  • [9] Spyridopoulos I., Hoffmann J., Aicher A., Brummendorf T.H.,Doerr H.W., Zeiher A.M. et al., Accelerated Telomere Shorteningin Leukocyte Subpopulations of Patients With Coronary HeartDisease, Circulation, 2009, 120, 1364-1372[WoS]
  • [10] Nan W.Q., Ling Z., Bing C., The influence of the telomeretelomerasesystem on diabetes mellitus and its vascularcomplications, Expert Opin. Ther. Targets., 2015, 19(6)
  • [11] Ji Y.N., An L., Zhan P., Chen X.H., Cytomegalovirus infection andcoronary heart disease risk: a meta-analysis, Molecular BiologyReports, 2012, 39(6), 6537-6546[WoS][Crossref]
  • [12] Mendy A., Gasana J., Vieira E.R., Diallo H., Prospective studyof cytomegalovirus seropositivity and risk of mortality fromdiabetes, Acta Diabetol., 2014, 51, 723-729[WoS]
  • [13] Green M., Michaels M.G., Epstein-Barr Virus Infectionand Posttransplant Lymphoproliferative Disorder, Am. J.Transplant., 2013, 13(s3), 41-54[Crossref][WoS]
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