Profile of adult acute cholinesterase inhibitors
substances poisoning – a 30 years analysis

• Authors: Eugen N. Gazzi , Victorita Sorodoc , Irina M. Jaba , Catalina Lionte , Cristina Bologa , Catalina E. Lupusoru , Raoul Lupusoru , Laurentiu Sorodoc , Ovidiu Petris
• Languages of publication: EN

Abstracts

EN

Objectives: The objective of this study was to
assess the pattern and outcome of acute cholinesterase
inhibitors substances (CIS) poisoning cases, in a
cohort from a regional tertiary care hospital. Methods:
cases admitted in the Toxicology Clinic of “Sf. Spiridon”
Emergency Clinic Hospital Iasi, Romania between 1983
and 2013 were studied. Results: a total number of 606
patients were included. The reason for exposures was
intentional in 70% of cases and the commonest route of
poisoning was oral in 92.2%. The highest percent of cases
was females (56.4), the age group 20-29 (25.4%) and the
majority (66.7%) coming from rural areas, 28.2% being
agricultural workers. 36.6% of cases were severe clinical
forms. Overall mortality rates were 3.8%, more than half
of the death patients (65.2%) had concomitant alcohol
intake. It was a significant statistical association between
decrease level of serum cholinesterase on admittance and
severe forms (p 0.000) and between survival and deaths
groups (p 0.000). The pattern of poisoning described by
our retrospective study suggests that CIS poisoning are
mainly preventable. The main effective goals for prevention
are restriction in free accessibility to toxic pesticides,
together with sustained efforts in education concerning
the life-threatening danger of pesticide poisoning.

Keywords

EN

Epidemiology; pesticide; toxicity

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2014
• Volume: 10
• Issue: 1

Dates

received

18 - 9 - 2014

accepted

31 - 3 - 2015

online

8 - 5 - 2015

Contributors

author

Eugen N. Gazzi

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

author

Victorita Sorodoc

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

author

Irina M. Jaba

• Pharmacology – Toxicology Department,
  Faculty of Medicine, „Gr. T. Popa” University of Medicine
  and Pharmacy, Iasi, Romania

author

Catalina Lionte

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

author

Cristina Bologa

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

author

Catalina E. Lupusoru

• Pharmacology – Toxicology Department,
  Faculty of Medicine, „Gr. T. Popa” University of Medicine
  and Pharmacy, Iasi, Romania

author

Raoul Lupusoru

• Physiopathology Department, Faculty of Medicine,
  „Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

author

Laurentiu Sorodoc

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

author

Ovidiu Petris

• „Sf. Spiridon” Emergency Clinic Hospital, Internal Medicine
  and Toxicology Department, School of Medicine „Gr. T. Popa”
  University of Medicine and Pharmacy, Iasi, Romania

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Identifiers

DOI

10.1515/med-2015-0041