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2014 | 10 | 1 |
Article title

Profile of adult acute cholinesterase inhibitors
substances poisoning – a 30 years analysis

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Objectives: The objective of this study was to
assess the pattern and outcome of acute cholinesterase
inhibitors substances (CIS) poisoning cases, in a
cohort from a regional tertiary care hospital. Methods:
cases admitted in the Toxicology Clinic of “Sf. Spiridon”
Emergency Clinic Hospital Iasi, Romania between 1983
and 2013 were studied. Results: a total number of 606
patients were included. The reason for exposures was
intentional in 70% of cases and the commonest route of
poisoning was oral in 92.2%. The highest percent of cases
was females (56.4), the age group 20-29 (25.4%) and the
majority (66.7%) coming from rural areas, 28.2% being
agricultural workers. 36.6% of cases were severe clinical
forms. Overall mortality rates were 3.8%, more than half
of the death patients (65.2%) had concomitant alcohol
intake. It was a significant statistical association between
decrease level of serum cholinesterase on admittance and
severe forms (p 0.000) and between survival and deaths
groups (p 0.000). The pattern of poisoning described by
our retrospective study suggests that CIS poisoning are
mainly preventable. The main effective goals for prevention
are restriction in free accessibility to toxic pesticides,
together with sustained efforts in education concerning
the life-threatening danger of pesticide poisoning.
Physical description
18 - 9 - 2014
31 - 3 - 2015
8 - 5 - 2015
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