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2014 | 10 | 1 |

Article title

Postprandial decrease in LDL-cholesterol in men
with metabolic syndrome


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Background: In some epidemiological studies,
blood lipids are determined at non-fasting state, which
may impact cardiovascular risk estimation. The aim of
this study was to evaluate postprandial LDL-C changes in
men with newly diagnosed metabolic syndrome (MetSy).
Methods: 36 male patients were examined: 12 men with
and 24 men without MetSy. The fat tolerance test was
performed before and after a three-month hypolipidemic
treatment. Serum lipids were measured using routine
methods, lipid peroxides (LPO) colorimetrically, apoli-
poproteins A-I, B, and hsCRP immunoturbidimetrically.
Results: The postprandial increase in triglycerides was
associated with a decrease in LDL-C and a small decrease
in apo B. In men with MetSy, the mean change in LDL-C
(-19.5 ± 2.3 mg/dl) was greater than in healthy men (-5.7 ±
3.8 mg/dl). All lipid changes (ΔTG, ΔLDL-C and ΔLPO) were
linearly dependent on the postprandial non-LDL-choles-
terol. After three months of hypolipidemic treatment, in
all men with MetSy, the apoB/apoA-I ratio remained the
same as before the therapy. Conclusion: In men diagnosed
with MetSy, postprandial decreases in LDL-cholesterol
may cause underestimation of cardiovascular risk. After
three months of hypolipidemic treatment, there was only
a partial reduction in this risk, as the apoB/apoA-I ratio
remained the same.








Physical description


20 - 10 - 2013
3 - 2 - 2015
31 - 3 - 2014


  • Wroclaw Medical University, Department of Internal and Occupational Diseases, and Hypertension, Borowska 213, 50-556 Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland
  • Department of Internal Diseases and Hypertension, Wroclaw Medical University, Wrocław, Poland


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