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Number of results

Journal

2014 | 10 | 1 |

Article title

Trefoil factor 3 as a marker of intestinal cell damage during sepsis

Content

Title variants

Languages of publication

EN

Abstracts

EN
Objective: Gastrointestinal dysfunction or gut
failure frequently occurs in seriously ill patients and can
be responsible for multi-organ failure. Trefoil factor 3
(TFF3) was characterized for its role in reconstitution of an
epithelial barrier after mucosal injury in the jejunum. The
aims of our study was an analysis of TFF3 levels dynamics
in patients with sepsis and the correlation of TFF3 with
severity of sepsis and mortality. Methods: Prospective observational study, a ten days evaluation
period in children aged 0-19 years with systemic
inflammatory response syndrome or septic state. Blood
tests to determine levels of TFF3 were obtained as long
as the patient met the criteria for systemic inflammatory
response syndrome or sepsis. Results: Analysis of dynamics revealed steady levels of
TFF3 during the 10 day period evaluated. TFF3 levels
could not differentiate between various septic conditions
in patients until a marked organ dysfunction developed.
Higher Area Under Curve was noticed between control
group and patients with sepsis. We could not make any
strong conclusions based on mortality model. Conclusions: Levels of TFF3 are elevated in paediatric
patients with sepsis through organ dysfunction.

Publisher

Journal

Year

Volume

10

Issue

1

Physical description

Dates

accepted
11 - 12 - 2014
online
24 - 4 - 2015
received
28 - 8 - 2013

Contributors

author
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
author
  • Faculty of Medicine, Masaryk University, Černopolní 9,
    Brno, 62500, Czech Republic
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
author
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_med-2015-0020
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