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2014 | 10 | 1 |

Article title

Trefoil factor 3 as a marker of intestinal cell damage during sepsis


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Objective: Gastrointestinal dysfunction or gut
failure frequently occurs in seriously ill patients and can
be responsible for multi-organ failure. Trefoil factor 3
(TFF3) was characterized for its role in reconstitution of an
epithelial barrier after mucosal injury in the jejunum. The
aims of our study was an analysis of TFF3 levels dynamics
in patients with sepsis and the correlation of TFF3 with
severity of sepsis and mortality. Methods: Prospective observational study, a ten days evaluation
period in children aged 0-19 years with systemic
inflammatory response syndrome or septic state. Blood
tests to determine levels of TFF3 were obtained as long
as the patient met the criteria for systemic inflammatory
response syndrome or sepsis. Results: Analysis of dynamics revealed steady levels of
TFF3 during the 10 day period evaluated. TFF3 levels
could not differentiate between various septic conditions
in patients until a marked organ dysfunction developed.
Higher Area Under Curve was noticed between control
group and patients with sepsis. We could not make any
strong conclusions based on mortality model. Conclusions: Levels of TFF3 are elevated in paediatric
patients with sepsis through organ dysfunction.








Physical description


11 - 12 - 2014
24 - 4 - 2015
28 - 8 - 2013


  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
  • Faculty of Medicine, Masaryk University, Černopolní 9,
    Brno, 62500, Czech Republic
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic
  • University Children‘s Hospital,
    Department of Anesthesia and Intensive Care, Černopolní 9, Brno,
    62500, Czech Republic


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