European Society of Cardiology Guidelines cite
results of meta-analysis that the use of calcium channel
blockers results in fewer angina episodes per week vs.
long-acting nitrates. Moreover, we listed 12 reasons more
to prefer amlodipine over long-acting nitrates, especially
in stable angina pectoris patients with arterial hypertension.
It may be the way to decrease polypharmacy without
loosing efficacy. Some important advantages of amlodipine
versus long-acting nitrate(s) are: amlodipine also
treats hypertension, it helps reducing hypertensive target organ damages (e.g. left ventricular hypertrophy) and prevents
morning blood pressure surge. Moreover, amlodipine
can be given once daily (which improves adherence),
it produces neither tolerance nor rebound, it has less side