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Journal
2014 | 10 | 1 |
Article title

Correlation between SNPs in CDH1 and gastric
cancer in Chinese population

Content
Title variants
Languages of publication
EN
Abstracts
EN
Background. Many recent studies revealed that
the single nucleotide polymorphisms have considerable
effects on the susceptibility of cancer, such as prostate
cancer, lung cancer and gastric cancer. The E-cadherin, a
calcium-dependent transmembrane glycoprotein encoded
by CDH1 gene, is critical for epithelial construction, intercellular
adhesion and cell migration. Some associations
have been reported between single nucleotide polymorphisms
and gastric cancer in the Chinese population.
Objective. To investigate whether the single nucleotide
polymorphism in CDH1 gene is associated with the susceptibility
of gastric cancer in the Chinese population.
Material and methods. The genotypes of 5 known single
nucleotide polymorphisms (rs33935154, rs121964871,
rs121964874, rs121964875, rs121964876) were determined in 359 gastric cancer patients and 368 healthy controls.
High resolution melting curve detection and sequencing
analysis were used in the present study. Results. There
is a statistical significance in the rs121964871 C>G polymorphism
between gastric cancer patients and healthy
controls (OR=1.769, 95%CI: 1.051-2.976). Elderly male individuals
(>50 years of age) carrying this risk factor may
be more susceptible to gastric cancer. Conclusions. The
results indicated that the rs121964871 C>G polymorphism
is associated with the susceptibility of gastric cancer in
the Chinese population, with some age and sex-dependent
tendencies observed.
Publisher
Journal
Year
Volume
10
Issue
1
Physical description
Dates
published
1 - 1 - 2015
received
20 - 7 - 2014
accepted
28 - 8 - 2014
online
3 - 11 - 2014
References
  • [1] T. Ushijima, M. Sasako, Focus on gastric cancer, Cancer Cell 5(2004) 121-125.[Crossref]
  • [2] K. Nakamura, H. Sugano, K. Takagi, Carcinoma of thestomach in incipient phase: its histogenesis and histologicalappearances, Gann 59 (1968) 251-258.
  • [3] P. Lauren, The Two Histological Main Types of GastricCarcinoma: Diffuse and So-Called Intestinal-Type Carcinoma.An Attempt at a Histo-Clinical Classification, Acta PatholMicrobiol Scand 64 (1965) 31-49.
  • [4] J.J. Bonenkamp, J. Hermans, M. Sasako, C.J. van de Velde,K. Welvaart, I. Songun, S. Meyer, J.T. Plukker, P. Van Elk, H. Obertop, D.J. Gouma, J.J. van Lanschot, C.W. Taat, P.W. deGraaf, M.F. von Meyenfeldt, H. Tilanus, G. Dutch Gastric Cancer,Extended lymph-node dissection for gastric cancer, N Engl JMed 340 (1999) 908-914.
  • [5] M.F. de Maat, C.J. van de Velde, N. Umetani, P. de Heer, H.Putter, A.Q. van Hoesel, G.A. Meijer, N.C. van Grieken, P.J.Kuppen, A.J. Bilchik, R.A. Tollenaar, D.S. Hoon, Epigeneticsilencing of cyclooxygenase-2 affects clinical outcome ingastric cancer, J Clin Oncol 25 (2007) 4887-4894.[Crossref]
  • [6] A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, M.J. Thun, Cancerstatistics, 2007, CA Cancer J Clin 57 (2007) 43-66.[Crossref]
  • [7] C. Martinez-Rico, F. Pincet, J.P. Thiery, S. Dufour, Integrinsstimulate E-cadherin-mediated intercellular adhesion byregulating Src-kinase activation and actomyosin contractility, JCell Sci 123 (2010) 712-722.[WoS]
  • [8] Kucharczak, S. Charrasse, F. Comunale, J. Zappulla, B. Robert,I. Teulon-Navarro, A. Pelegrin, C. Gauthier-Rouviere, R-Cadherinexpression inhibits myogenesis and induces myoblasttransformation via Rac1 GTPase, Cancer Res 68 (2008)6559-6568.[Crossref]
  • [9] S.C. Suzuki, M. Takeichi, Cadherins in neuronal morphogenesisand function, Dev Growth Differ 50 Suppl 1 (2008) S119-130.[WoS][Crossref]
  • [10] H.C. Chen, R.Y. Chu, P.N. Hsu, P.I. Hsu, J.Y. Lu, K.H. Lai, H.H.Tseng, N.H. Chou, M.S. Huang, C.J. Tseng, M. Hsiao, Loss ofE-cadherin expression correlates with poor differentiation andinvasion into adjacent organs in gastric adenocarcinomas,Cancer Lett 201 (2003) 97-106.
  • [11] U. Cavallaro, G. Christofori, Cell adhesion and signalling bycadherins and Ig-CAMs in cancer, Nat Rev Cancer 4 (2004)118-132.[Crossref]
  • [12] M. Wakui, [Analysis of single nucleotide polymorphisms(SNPs)], Rinsho Byori 61 (2013) 1008-1017.
  • [13] Y.X. Wang, L. Zhao, X.Y. Wang, C.M. Liu, S.G. Yu, Associationbetween E-cadherin (CDH1) polymorphisms and papillarythyroid carcinoma risk in Han Chinese population, Endocrine 41(2012) 526-531.[WoS]
  • [14] C. Sun, X. Liu, H. Zhang, W. Guo, Z. Cai, H. Chen, K. Zhang,D. Zhu, Y. Wang, Functional polymorphism of hOGG1 gene isassociated with type 2 diabetes mellitus in Chinese population,Mol Cell Endocrinol 325 (2010) 128-134.
  • [15] A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, D. Forman,Global cancer statistics, CA Cancer J Clin 61 (2011) 69-90.[Crossref]
  • [16] A.N. Milne, F. Carneiro, C. O’Morain, G.J. Offerhaus, Naturemeets nurture: molecular genetics of gastric cancer, Hum Genet126 (2009) 615-628.[WoS][Crossref]
  • [17] G.B. Grunwald, The structural and functional analysis ofcadherin calcium-dependent cell adhesion molecules, CurrOpin Cell Biol 5 (1993) 797-805.[Crossref]
  • [18] G. Berx, K.F. Becker, H. Hofler, F. van Roy, Mutations of thehuman E-cadherin (CDH1) gene, Hum Mutat 12 (1998) 226-237.[Crossref]
  • [19] C. Oliveira, R. Seruca, C. Caldas, Genetic screening forhereditary diffuse gastric cancer, Expert Rev Mol Diagn 3(2003) 201-215.[Crossref]
  • [20] M.S. Al-Moundhri, M. Al-Khanbashi, M. Al-Kindi, M.Al-Nabhani, I.A. Burney, A. Al-Farsi, B. Al-Bahrani, Associationof E-cadherin (CDH1) gene polymorphisms and gastric cancerrisk, World J Gastroenterol 16 (2010) 3432-3436.[WoS]
  • [21] Z. Zhan, J. Wu, J.F. Zhang, Y.P. Yang, S. Tong, C.B. Zhang, J. Li,X.W. Yang, W. Dong, CDH1 gene polymorphisms, plasma CDH1levels and risk of gastric cancer in a Chinese population, MolBiol Rep 39 (2012) 8107-8113.
  • [22] Q.H. Chen, W. Deng, X.W. Li, X.F. Liu, J.M. Wang, L.F. Wang,N. Xiao, Q. He, Y.P. Wang, Y.M. Fan, Novel CDH1 germlinemutations identified in Chinese gastric cancer patients, World JGastroenterol 19 (2013) 909-916.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_med-2015-0007
Identifiers
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