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2014 | 10 | 1 |

Article title

Endometrial cancer and microsatellite instability status


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Microsatellite instability (MSI) is an important
factor in the development of various cancers as an identifier
of a defective DNA mismatch repair system. The objective
of our study was to define the association between
microsatellite instability status and traditional clinicopathologic
characteristics of endometrioid type adenocarcinoma.
Material and methods: MSI status of endometrial
cancer was examined by employing the Promega
MSI Analysis System. This system uses 5 mononucleotide
markers to identify MSI in tumour and normal tissue DNA
(BAT-25, BAT-26, NR-21, NR-24, and MONO-27), and 2 pentanucleotide
markers (Penta C and Penta D) for specimen
identification. In this study, we investigated MSI status
in 109 endometrial carcinomas. Results and conclusions:
One hundred (92%) of 109 endometrial cancers showed
endometrioid type histology and only 9 (8%) non-endometrioid
type. MSI-high was found in 17% (17/100)
of endometrioid type adenocarcinomas, in 0% (0/9) of
non-endometrioid carcinomas. Selected clinicopathologic
parameters for endometrioid type adenocarcinomas were
compared to the MSI status which was separated into two
groups – MSI-high and MSI stable. The results showed
that MSI-high status was related to clinicopathologic
parameters such as deep myometrial invasion and higher
histologic grade in endometrioid type adenocarcinomas.








Physical description


11 - 11 - 2014
13 - 11 - 2013
29 - 8 - 2014


  • Out Patient Clinic, National
    cancer institute, Santariskiu 1, LT-08660, Vilnius, Lithuania
  • Promega Corporation, Madison WI, USA
  • Radiotherapy and Drug Therapy
    Center, National cancer institute, Santariskiu 1, LT-08660, Vilnius,
  • Scientific Research Center, National cancer institute,
    Santariskiu 1, LT-08660, Vilnius, Lithuania
  • Scientific Research Center, National cancer institute,
    Santariskiu 1, LT-08660, Vilnius, Lithuania
  • Promega Corporation, Madison WI, USA


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