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2014 | 10 | 1 |

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Isolated myeloid sarcoma of the neck and chest: differential diagnosis and therapeutic approach


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In this article, we present the case of a 57-yearold man with cervical and mediastinal tumor mass, normal blood count as well as virusological status. Cervical tumor tissue biopsy revealed cells positive for CD34, CD13, LCA, CD33, and CD163 but negative for T-cell and B-cell markers, NK-cell markers, plasmacytic markers and anaplastic large cell lymphoma markers. These features were consistent with myeloid sarcoma of the neck with involvement of the mediastinum. We discussed differential diagnosis and therapy of isolated myeloid sarcoma and suggest that clinical presentation, cell morphology, complete immunophenotype, and specific genotypic lesions in some cases, must be evaluated.








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1 - 1 - 2015
4 - 6 - 2014
8 - 10 - 2013
8 - 10 - 2014


  • Clinic for hematology, Clinical Center Kragujevac, Medical Faculty, University of Kragujevac
  • Clinic for hematology, Clinical Center Kragujevac, Medical Faculty, University of Kragujevac
  • Clinic for hematology, Clinical Center of Serbia, Koste Todorovica 2, 11 000 Belgrade, Serbia, Tel&fax +381 11 30 65 112


  • [1] Pileri SA, Orayi A, Falini B: Myeloid sarcoma. In Swerdlow S,Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J,Vardiman JW (eds) WHO classification of tumours of haematopoetic and lymphoid tissues. Lyon, IARC, 2008, pp 140-141
  • [2] Bakst RL, Tallman MS, Douer D, Yahalom J. How I treat extramedullary acute myeloid leukemia. Blood,2011,118(14),3785-3793[WoS][Crossref]
  • [3] Klco JM, Welch JS, Nguyen TT, Hurley MY, Kreisel FH, Hassan A et al. State of the art in myeloid sarcoma. Int J Lab Hematol., 2011,33(6),555-565[WoS][Crossref]
  • [4] Burns A. Observation of surgical anatomy, head and neck. Edinburgh: Thomas Royce and co;1811, pp 364-366
  • [5] King A. A case of chloroma. Monthly J med., 1853,17:97
  • [6] Rappaport H. Tumors of the hematopoetic system. Armed Forces Inst Pathol., 1966, 241-243
  • [7] Antic D, Elezovic I, Milic N, Suvajdzic N, Vidovic A, Perunicic M et al. Is there a “gold” standard treatment for patients with isolated myeloid sarcoma? Biomed Pharmacother., 2013,67(1),72-77[WoS][Crossref]
  • [8] Hutchinson RE, Kurec AS, Davey FR. Granulocytic sarcoma. Clin Lab Med., 1990, 10, 889-901
  • [9] Paydas S, Zorludemir S, Ergin M. Granulocytic sarcoma: 32 cases and review of the literature. Leuk Lymphoma., 2006, 47(12),2527-2541
  • [10] Antic D, Verstovsek S, Elezovic I, Grujicic D, Gotic M, Bila J et al. Spinal epidural granulocytic sarcoma in non-leukemic patient. Int J Hematol., 2009,89(1),95-97[WoS][Crossref]
  • [11] Antic D, Elezovic I, Bogdanovic A, Vukovic NS, Pavlovic A, Jovanovic MP et al. Isolated myeloid sarcoma of the gastrointestinal tract. Intern Med., 2010,49(9),853-856[Crossref][WoS]
  • [12] Colović N, Jurišić V, Terzić T, Jevtovic D, Colović M. Alveolar granulocytic sarcoma of the mandible in a patient with HIV. Onkologie, 2011,34(1-2),55-8[WoS][Crossref]
  • [13] Audouin J, Comperat E, Le Tourneau A, Camilleri- Broët S, Adida C, Molina T et al. Myeloid sarcoma: clinical and morphologic criteria useful for diagnosis Int J Surg Pathol., 2003,11(4),271-282[Crossref]
  • [14] Alexiev BA, Wang W, Ning Y, Chumsri S, Gojo I, Rodgers WH et al. Myeloid sarcomas: a histologic, immunohistochemical, and cytogenetic study. Diagn Pathol., 2007, 2:42[WoS][Crossref]
  • [15] Meis JM, Butler JJ, Osborne BM, Manning JT. Granulocytic sarcoma in nonleukemic patients. Cancer, 1986,58(12),2697-2709[Crossref]
  • [16] Byrd, J.C., Edenfield, W.J., Shields, D.J. and Dawson, N.A. Extramedullary myeloid cell tumors in acute nonlymphocytic leukemia: A Clinical Review J. Clin. Oncol.,1995, 13(7), 1800-1816
  • [17] Majhi U, Murhekar K, Sundersingh S. Primary myeloid sarcoma with megakaryocytic differentiation in lymph nodes and skin. Indian J Pathol Microbiol., 2011,54(3),660-1[WoS][Crossref]
  • [18] Elyamany G, Khan M, El Hag I, El-Zimaity M, Albalawi M, Al Abdulaaly A. Generalized Lymphadenopathy as the First Presentation of Granulocytic Sarcoma: A Diagnostic Challenge. Case Rep Med., 2013,2013,483291
  • [19] Kojima M, Nakamura S, Shimizu K, Yamane Y, Itoh H, Masawa N. Granulocytic sarcoma presenting with lymph node infarction at disease onset. APMIS, 2003,111(12),1133-6[Crossref]
  • [20] Breccia M, Mandelli F, Petti MC, D’Andrea M, Pescarmona E, Pileri SA et al. Clinicopathological characteristics of myeloid sarcoma at diagnosis and during follow-up: report of 12 cases from a single institution. Leuk Res., 2004,28(11),1165-1169[Crossref]
  • [21] Neiman RS, Barcos M, Berard C, Bonner H, Mann R, Rydell RE et al. Granulocytic sarcoma: a clinicopathologic study of 61 biopsed cases. Cancer 1981,48, 1426-1437[Crossref]
  • [22] Yamauchi K, Yasuda M. Comparison in treatments of nonleukemic granulocytic sarcoma: report of two cases and a review of 72 cases in the literature. Cancer. 2002,94(6),1739-1746[Crossref]
  • [23] Tsimberidou AM, Kantarjian HM, Wen S, Keating MJ, O’Brien S, Brandt M et al. Myeloid sarcoma is associated with superior event-free survival and overall survival compared with acute myeloid leukemia. Cancer. 2008,113(6),1370-1378[WoS][Crossref]
  • [24] Pileri SA Ascani S, Cox MC, Campidelli C, Bacci F, Piccioli M et al. Myeloid sarcoma: clinico pathologic, phenotypic and cytogenetic analysis of 92 adult patients. Leukemia. 2007, 21(2),340-350[WoS][Crossref]
  • [25] Lan TY, Lin DT, Tien HF, Yang RS, Chen CY, Wu K. Prognostic factors of treatment outcomes in patients with granulocytic sarcoma. Acta Haematol.,2009,122(4),238-246[WoS][Crossref]
  • [26] Chevallier P, Labopin M, Cornelissen J, Socié G, Rocha V, Mohty M; ALWP of EBMT. Allogeneic hematopoietic stem cell transplantation for isolated and leukemic myeloid sarcoma in adults: a report from the Acute Leukemia Working Party of the European group for Blood and Marrow Transplantation. Haemat ologica,2011,96(9),1391-1394
  • [27] Antic D, Milic N. systemic versus localized therapeutic approach for isolated myeloid sarcoma: meta-analysis of individual patient data. Haematologica, 2013, 98(s1),281. abstract n. 0667

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