Background: Diabetes mellitus is closely related to
pancreas cancer. In this study we aimed to investigate
the effect of hyperglycemia on tumor and inflammation
markers, as well as pancreatic exocrine functions.Methods: A total of 98 consecutive diabetic patients
with poor glycemic control, and 50 healthy controls were
included in the study. We measured hsCRP, erythrocyte
sedimentation rate (ESR), CA19-9, CEA, amylase and lipase
in addition to routine biochemistry tests, before and after
euglycemia was achieved.Results: Fasting blood glucose, HbA1c, CA19-9,CEA,
hsCRP, ESR, triglycerides, AST, ALT, GGT, ALP, total
cholesterol and LDL-C levels decreased significantly with
the regulation of glycemic control. Amylase and lipase
levels increased with the regulation of glycemic control.
After glycemic control, CA19-9 and CEA levels were still
higher, whereas amylase and lipase levels were still lower
in the diabetic group compared with the control group.
Basal HbA1c showed significant correlation with CA19-9,
CEA, amylaseand lipase.Conclusions: We propose to repeat observations of tumor
markers after hyperglycemia is resolved, in order to avoid
unnecessary invasive tests. Our data also suggest that
pancreatic exocrine function was improved with lowering
blood glucose in a short period of time.