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2015 | 28 | 3 | 200-203
Article title

Organ and prenatal toxicity of nonsteroidal anti-inflammatory drugs

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EN
Abstracts
EN
Non-selective cyclooxygenase (COX) inhibitors, commonly referred to as nonsteroidal anti-inflammatory drugs (NSAIDs), are among the most taken pharmaceuticals. In adults, they can have a series of side effects, including especially gastroenterotoxicity, hepatotoxicity, nephrotoxicity, chondrotoxicity, and neurotoxicity, and they can induce allergic reactions. Any exacerbation of symptoms depends on the chemical structure of the drug, its dosage and duration of exposure, individual sensitivity, comorbidities and the degree of inhibition of basic COX isoenzymes - the constitutive (COX-2) and induced (COX-1) expressions. However, data on prenatal toxicity are inconsistent. Classic nonselective COX inhibitors do not result in an increase in the risk of developing significant congenital defects; however, if used in the late-pregnancy period, they can have an adverse effect on the foetus, by inducing the premature closure of the ductus arteriosus and by producing a tocolytic effect. Individual reports also indicate the increased risk of developing heart and anterior abdominal wall defects, as well as hypospadias.
Publisher

Year
Volume
28
Issue
3
Pages
200-203
Physical description
Dates
published
1 - 9 - 2015
online
26 - 11 - 2015
accepted
26 - 8 - 2015
received
9 - 7 - 2015
Contributors
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Chair and Department of Rehabilitation and Orthopaedics, Medical University of Lublin, Jaczewskiego 8, 20-950 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
author
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
author
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland
  • Human Anatomy Department, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland, wojciech686@wp.pl
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0072
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