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2015 | 28 | 2 | 77-80

Article title

The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp.

Content

Title variants

Languages of publication

EN

Abstracts

EN
The ongoing control of virulent bacteria strains is a challenge for today’s medicine. An example of this, is one widely used drug employed in treating less serious external oral and ocular bacterial infections. This is a gel containing both cetalkonium chloride and choline salicylate. However, whether in the era of expanding bacterial resistance this gel is still effective, is not clear. Hence, in our work, its antibacterial effect was studied against 13 strains of Pseudomonas aeruginosa, 6 strains of Staphylococcus spp. and 6 strains of Streptococcus spp. drawn from the collection of the Department of Microbiology, Virology and Immunology, Kazakh National Medical University, as well as against 30 strains of Staphylococcus spp. recently isolated from Kazakh medical students. This work demonstrated that Pseudomonas aeruginosa was insensitive to this preparation in all samples, while the sensitivity of Staphylococcus spp. and Streptococcus spp. was almost halved, compared to untreated samples. An interesting discovery was the greater resistance of strains obtained from student volunteers than from the collection. However, despite the evident resistance of some strains to the combined cetalkonium chloride and choline salicylate gel, we put forward that it can still be used in less serious external bacterial infections.

Publisher

Year

Volume

28

Issue

2

Pages

77-80

Physical description

Dates

published
1 - 6 - 2015
online
16 - 7 - 2015
received
25 - 3 - 2015
accepted
28 - 4 - 2015

Contributors

  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • DRK Biomedical Research and Development LLC, 788 Los Alamos avenue, Livermore, CA, USA
  • Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
author
  • Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland

References

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  • 13. Oman T. K. et al.: Topical choline salicylates implicated in Reye’s syndrome. BMJ, 336, 1376, 2008.
  • 14. Patterson M.J. (1996). Streptococcus. In: Baron’s Medical Microbiology (Baron S. et al., eds.) (4th ed.). Univ of Texas Medical Branch.
  • 15. Raggi C., et al.: Methicillin Resistance, Biofilm Formation and Resistance to Benzalkonium Chloride in Staphylococcus aureus Clinical Isolates. Clin. Microbial., 2, 3, 2013.
  • 16. Tarbox B.B. et al.: Benzalkonium chloride. A potential disinfecting irrigation solution for orthopaedic wounds. Clin Orthop Relat Res., 346, 257, 1998.
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  • 18. Waters A.E. et al.: Multidrug-Resistant Staphylococcus aureus in US Meat and Poultry. Clin. Infect. Dis., 52, 1227, 2011.[WoS]

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0048
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