PL EN


Preferences help
enabled [disable] Abstract
Number of results
2015 | 28 | 2 | 77-80
Article title

The effect of a combined choline salicylate and cetalkonium chloride gel on particular strains of Pseudomonas aeruginosa, Staphylococcus spp. and Streptococcus spp.

Content
Title variants
Languages of publication
EN
Abstracts
EN
The ongoing control of virulent bacteria strains is a challenge for today’s medicine. An example of this, is one widely used drug employed in treating less serious external oral and ocular bacterial infections. This is a gel containing both cetalkonium chloride and choline salicylate. However, whether in the era of expanding bacterial resistance this gel is still effective, is not clear. Hence, in our work, its antibacterial effect was studied against 13 strains of Pseudomonas aeruginosa, 6 strains of Staphylococcus spp. and 6 strains of Streptococcus spp. drawn from the collection of the Department of Microbiology, Virology and Immunology, Kazakh National Medical University, as well as against 30 strains of Staphylococcus spp. recently isolated from Kazakh medical students. This work demonstrated that Pseudomonas aeruginosa was insensitive to this preparation in all samples, while the sensitivity of Staphylococcus spp. and Streptococcus spp. was almost halved, compared to untreated samples. An interesting discovery was the greater resistance of strains obtained from student volunteers than from the collection. However, despite the evident resistance of some strains to the combined cetalkonium chloride and choline salicylate gel, we put forward that it can still be used in less serious external bacterial infections.
Publisher

Year
Volume
28
Issue
2
Pages
77-80
Physical description
Dates
published
1 - 6 - 2015
online
16 - 7 - 2015
received
25 - 3 - 2015
accepted
28 - 4 - 2015
Contributors
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • DRK Biomedical Research and Development LLC, 788 Los Alamos avenue, Livermore, CA, USA
  • Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland, andrzejpolski@umlub.pl
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
  • Department of Microbiology, Virology and Immunology, Kazakh National Medical University, 88 Tole Bi Street, Almaty, Kazakhstan
author
  • Chair and Department of Applied Pharmacy, Faculty of Pharmacy, Medical University of Lublin, 1 Chodzki, 20-093 Lublin, Poland
References
  • 1. Akimitsu N., Hamamoto H., Inoue R.: Increase in Resistance of Methicillin-Resistant Staphylococcus aureus to β-Lactams Caused by Mutations Conferring Resistance to Benzalkonium Chloride, a Disinfectant Widely Used in Hospitals. Antimicrob. Agents Chemother., 43, 3042, 1999.
  • 2. Al-Masaudi S.B., Day M. J., Russell A. D.: Sensitivity of methicillinresistant Staphylococcus aureus strains to some antibiotics, antiseptics and disinfectants. J. Appl. Bacteriol., 65, 330, 1988.
  • 3. Balcht A., Smith R.: Pseudomonas aeruginosa: Infections and Treatment. Informa. Healthcare., 2, 83, 1994.
  • 4. Bengani L.C., Chauhan A.: Extended delivery of an anionic drug by contact lens loaded with a cationic surfactant. Biomaterials, 34, 2817, 2013.[WoS]
  • 5. Cole A.M. et al.: Determinants of Staphylococcus aureus nasal carriage. Clin. Diagn. Lab. Immunol., 8, 1066, 2001.
  • 6. Ferrero-Miliani L. et al.: Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin. Exp. Immunol., 147, 227, 2007.
  • 7. Harrison J.J. et al.: Copper and Quaternary Ammonium Cations Exert Synergistic Bactericidal and Antibiofilm Activity against Pseudomonas aeruginosa. Antimicrob. Agents Chemother., 52, 2874, 2008.
  • 8. Kluytmans J. et al.: Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin. Microbiol. Rev., 10, 508, 1997.
  • 9. Lallemand F. et al.: Successfully improving ocular drug delivery using the cationic nanoemulsion, novasorb. J. Drug Deliv., 604204, 3, 2012.
  • 10. Martindale: The Complete Drug Reference. [online] London: Pharmaceutical Press. http://www.medicinescomplete.com (cited: 07.01.2015).
  • 11. Micromedex® 2.0, (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Available at: http://www.micromedexsolutions.com/ (cited: 12.01.2015).
  • 12. Mosca F., Russo F., Miragliotta G.: (2006) In vitro antimicrobial activity of benzalkonium chloride against clinical isolates of Streptococcus agalactiae. J. Antimicrob. Chemother., 57, 566, 2006.
  • 13. Oman T. K. et al.: Topical choline salicylates implicated in Reye’s syndrome. BMJ, 336, 1376, 2008.
  • 14. Patterson M.J. (1996). Streptococcus. In: Baron’s Medical Microbiology (Baron S. et al., eds.) (4th ed.). Univ of Texas Medical Branch.
  • 15. Raggi C., et al.: Methicillin Resistance, Biofilm Formation and Resistance to Benzalkonium Chloride in Staphylococcus aureus Clinical Isolates. Clin. Microbial., 2, 3, 2013.
  • 16. Tarbox B.B. et al.: Benzalkonium chloride. A potential disinfecting irrigation solution for orthopaedic wounds. Clin Orthop Relat Res., 346, 257, 1998.
  • 17. Vane J.R., Botting R.M.: New insight into the mode of action of ant-inflammatory drugs. Inflamm. Res., 44, 2, 1995.[Crossref]
  • 18. Waters A.E. et al.: Multidrug-Resistant Staphylococcus aureus in US Meat and Poultry. Clin. Infect. Dis., 52, 1227, 2011.[WoS]
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0048
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.