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2015 | 28 | 1 | 33-36

Article title

Overview on fosfomycin and its current and future clinical significance

Content

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Languages of publication

EN

Abstracts

EN
Fosfomycin is an old antibiotic with a unique chemical structure and with broadspectrum activity against numerous bacterial pathogens, both Gram-positive and Gramnegative, including resistant and multi-resistant strains. This antibiotic was accepted into clinical practice in the early 1970s. Its use, however, has been limited for several years for treating mainly lower uncomplicated urinary tract infections (in the form of fosfomycin trometamol taken orally). Nowadays, many clinicians and scientists are looking at this antibacterial drug for its employment in the treatment of severe infections caused by multi-resistant bacteria. Fosfomycin as an intravenous formulation (fosfomycin disodium) achieves clinically relevant concentrations in the serum and the cerebrospinal fluid, in kidney, bladder wall, prostate, lungs, bone and heart valves tissues, as well as in inflamed tissues and abscess fluid. The available clinical studies confirmed the efficacy of intravenous fosfomycin for the management of severe infections caused by multiresistant pathogens.

Publisher

Year

Volume

28

Issue

1

Pages

33-36

Physical description

Dates

published
1 - 3 - 2015
accepted
18 - 3 - 2015
received
2 - 3 - 2015
online
9 - 5 - 2015

Contributors

  • Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Medical University of Lublin, Poland
  • Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Medical University of Lublin, Poland
author
  • Public District Hospital in Krasnystaw, Poland
  • Chair and Clinic Infection Diseases, Independent Public Teaching Hospital No 1 in Lublin, Poland
author
  • Department of Pharmaceutical Microbiology with Laboratory for Microbiological Diagnostics, Medical University of Lublin, Poland

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_cipms-2015-0039
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