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2014 | 27 | 4 | 229-233

Article title

Apoptotic factors in physiological and pathological processes of teeth and periodontal tissues – literature review


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Apoptosis is a physiological process that occurs in the human body throughout the entire life span. This process can be seen in the tissues of the stomatognathic system. A disorder in such programmed cell death processes leads to the development of pathological lesions. Among these are inflammation, osteolytic lesions and neoplastic hyperplasia. We put forward that future studies should concentrate on how to use the knowledge of apoptotic processes and their inhibitors in therapeutic processes involving the stomatognathic system.










Physical description


1 - 12 - 2014
2 - 12 - 2014
3 - 11 - 2014
3 - 3 - 2015


  • Department of Oral Surgery, Medical University of Lublin, 7 Karmelicka, 20-081 Lublin, Poland
  • Department of Oral Surgery, Medical University of Lublin, 7 Karmelicka, 20-081 Lublin, Poland
  • Department of Oral Surgery, Medical University of Lublin, 7 Karmelicka, 20-081 Lublin, Poland
  • Student Research Group, Dept. of Oral Surgery, Medical University of Lublin


  • 1. Bielak- Żmijewska A.: Resistance to apoptosis mechanisms of neoplastic cells., Kosmos problemy nauk biologicznych., 52,2-3,2003
  • 2. Edamatsu M., et all.: Apoptosis - related factors in the epithelial components of dental follicles and dentigerous cysts associated with impacted third molars of the mandible., Oral Surg Oral Med Oral Pathol Oral Radiol Endod., 99,17,2005
  • 3. Filip A.: Apoptosis - programmed cell death., Cz I Almamater., 1,46,2003
  • 4. Filip A.: Apoptosis - programmed cell death., Cz II Almamater., 2,47,2003
  • 5. Kichi E., et all.: Cell proliferation, apoptosis and apoptosis-related factors in odontogenic keratocysts and in dentigerous cysts., J Oral Pathol Med., 34,280,2005
  • 6. Lee J.H., et all.: Dental follicle cells and cementoblasts induce apoptosis of ameloblast- lineage and Hartwig’s epithelial root sheath/ epithelial rests of Malassez cells through the Fas-Fas ligand pathway., Eur J Oral Sci., 29,120,2012[Crossref]
  • 7. Lin S.K., et all.: Nitric oxide promotes the progression of periapical lesion via inducing macrophage and osteoblast apoptosis., Oral Microbiol Immunol., 24,22,2007
  • 8. Loyola A. M., et all.: Apoptosis in epithelial cells of apical radicular cysts., International Endodondic Journal., 38, 465, 2005[Crossref]
  • 9. Matalova E., et all.: Caspase-7 participates in differentiation of cells forming dental hard tissues., Develop. Growth Differ., 615,55,2013
  • 10. Mitrus I., Missol- Kolka E., Szala S.: Pro-apoptotic genes in gene therapy of neoplasms., Współczesna Onkologia., 5,6,2001
  • 11. Nagai H., et all.: Inducible nitric oxide synthase and apoptosis related factors in the synovial tissues of temporomandibular joints with internal derangement and osteoarthritis., American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg., 61, 801, 2003
  • 12. Rahman F., et all.: Analysis of the immuno-expression of Ki-67 and bcl-2 in the pericoronal tissues of impacted teeth, dentinogerous cysts and gingiva using software image analysis., Dent Res. J., 1,10,2013
  • 13. Rakprasitkul S., et all.: Pathologic changes in the pericoronal tissues of un-erupted third molars., Oral Medicine.,
  • 14. Rana M.W., et all.: Detection of apoptosis during orthodontic tooth movement in rats., American Journal of Orthodontics and Dentofacial orthopedics., 119,5,2001
  • 15. Rangiani A., Motahhary P.: Evaluation of bax and bcl2 expression in odotogenic keratocysts and orthokeratinized odontogenic cysts: A comparison of two cysts., Oral Oncology., 2008
  • 16. Razavi S.M., et all.: The relation of pericoronal third molar follicle dimension and bcl-2/ki-67 expression: An immunohistochemical study., Dent Res. J., 1,9,2012
  • 17. Rodrigues L.V., et all.: Apoptosis in pulp elimination during physiological root resorption in human primary teeth., Braz. Dent. J., 20, 3, 2009
  • 18. Suzuki T., et all.: Immunohistochemical analysis of apoptosis-related factors in lining epithelium of radicular cysts., J Oral Patho Med., 34, 46, 2005
  • 19. Takahashi K., et all.: Cell synthesis, proliferation and apoptosis in human dental periapical lesions analysed by in situ hybridisation and immunohistochemistry., Oral Diseases., 320, 5, 1999
  • 20. Toslos K. I., Kakarantza-Angelopoulou E., Kapranos N.: Immunohistochemical study of bcl-2 protein, Ki-67 antigen and p53 protein in epithelium of glandular odontogenic cysts and dentigerous cysts., J Oral Pathol Med., 29, 44, 2000
  • 21. Wu T., et all.: Hydrogen Peroxide induces apoptosis in human dental pulp cells via Caspase-9 dependent pathway., JOE., 39,9,2013
  • 22. Vermelin L., Lecolle S., Septier D. et all: Apoptosis in human and rat dental pulp., Eur J Oral Sci., 547,104,1996 [Crossref]

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