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Number of results


2015 | 13 | 1 |

Article title

Supercritical carbon dioxide hops extracts
with antimicrobial properties


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Physical description


11 - 9 - 2015
23 - 2 - 2015
27 - 7 - 2015


  • New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland
  • Institute for Medicinal Plant Research “Dr Josif Pančić”, Tadeuša Košćuška 1, 11000 Belgrade, Serbia
  • University of Belgrade, Faculty of Veterinary Medicine, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia
  • University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11000 Belgrade, Serbia
  • University of Niš, Faculty of Medicine, Dr Zoran Djindjić 81, 18000 Niš, Serbia
  • New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland
  • New Chemical Syntheses Institute, Al. Tysiąclecia Państwa Polskiego 13A, 24-110 Puławy, Poland


  • [1] Zanoli P., Zavatti M., Pharmacognostic and pharmacological profile of Humulus lupulus L., J. Ethnopharmacol., 2008, 116, 383-396.[WoS]
  • [2] Obara K., Mizutani M., Hitomi Y., Yajima H., Kondo K., Isohumulones, the bitter component of beer, improve hyperglycemia and decrease body fat in Japanase subjects with prediabetes, Clin. Nutr., 2009, 28, 278-284.[Crossref]
  • [3] Negri G., Di Santi D., Tabach R., Bitter acids from hydroethanolic extracts of Humulus lupulus L., Cannabaceae, used as anxiolytic, Rev. Bras. Farmacogn., 2010, 20, 850-859.[WoS][Crossref]
  • [4] Yamaguchi N., Satoh-Yamaguchi K., Ono M., In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris, Phytomedicine, 2009, 16, 369-376.[WoS][Crossref]
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  • [10] Gerhäuser C., Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites, Mol. Nutr. Food Res., 2005, 49, 827-831.
  • [11] Teuber M., Schmareck A.F., Membrane leakage in Bacillus subtilis 168 induced by the hop constituents lupulone, humulone, isohumulone and humulinic acid, Arch. Mikrobiol., 1973, 94, 159-171.
  • [12] Schmalreck A.F., Teuber M., Reininger W., Hartl A., Structural features determining antibiotic potencies of natural and synthetic hop bitter resins, their precursors and derivatives, Can. J. Microbiol., 1975, 21, 205-212.[Crossref]
  • [13] Van Cleemput M., Cattoor K., De Bosscher K., Haegemang., De Keukeleire D., Heyerick A., Hop (Humulus lupulus)-derived bitter acids as multipotent bioactive compounds, J. Nat. Prod., 2009, 72, 1220-1230.[WoS]
  • [14] Teuber M., Low antibiotic potency of isohumulone, Appl. Microbiol., 1970, 19, 871.
  • [15] Yoshimaru T., Komatsu M., Tashiro E., Imoto M., Osada H., Miyoshi Y., et al., Xanthohumol suppresses oestrogen-signalling in breast cancer through the inhibition of BIG3-PHB2 interactions, Sci. Rep., 2014, 4, 7355, DOI: 10.1038/srep07355.
  • [16] Zhao F., Watanabe Y., Nozawa H., Daikonnya A., Kondo K., Kitanaka S., Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus), J. Nat. Prod., 2005, 68, 43-49.[Crossref]
  • [17] Kostrzewa D., Dobrzyńska-Inger A., Rój E., Experimental data on xanthohumol solubility in supercritical carbon dioxide, Fluid Phase Equilib., 2013, 360, 445-450.
  • [18] Adams R.P., Identification of Essential Oil Components by Gas Chromatography/Mass Spectrometry, 4th ed., Allured Publishing Corporation, Carol Stream, IL, USA, 2007.
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  • [20] Clinical and Laboratory Standards Institute, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; Approved standard-6th edition. M7-A6, Clinical and Laboratory Standards Institute, Wayne, PA, USA, 14, 2003.
  • [21] Taniguchi Y., Matsukura Y., Ozaki H., Nishimura K., Shindo K., Identification and quantification of the oxidation products derived from α-acids and β-acids during storage of hops ( Humulus lupulus L.), J Agric Food Chem., 2013, 61, 3121-3130.[WoS]
  • [22] James P., Tynan T., Murrough I. Mc., Byrne J., Preparation, purification and separation by high performance liquid chromatography of humulinic acids, dehydrohumulinic acids, and hulupones, J. Inst. Brew., 1990, 96, 137-141.
  • [23] Zhang X., Liang X., Xiao H., Xu Q., Direct characterization of bitter acids in a crude hop extract by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry, J. Am. Soc. Mass Spectrom., 2004, 15, 180-187.
  • [24] Ligor M., Stankevičius M., Wenda-Piesik A., Obelevičius K., Ragažinskienė O., Stanius Ž., et al., Comparative gas chromatographic–Mass spectrometric evaluation of hop (Humulus lupulus L.) essential oils and extracts obtained using different sample preparation methods, Food Anal. Method., 2014, 7, 1433-1442.[WoS][Crossref]
  • [25] Helmja K., Vaher M., Püssa T., Kamsol K., Orav A., Kaljurand M., Bioactive components of the hop strobilus: comparison of different extraction methods by capillary electrophoretic and chromatographic methods, J. Chromatogr. A, 2007, 1155, 222-229.[WoS]
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  • [27] Lu X., Liu J., Hou F., Liu Z., Cao X., Seo H., Gao B., Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway, Cell Stress Chaperon., 2011, 16, 539-548. [WoS][Crossref]

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