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Journal
2015 | 13 | 1 |
Article title

Retention, separation selectivity and system efficiency of selected basic psychotropic drugs on different RPLC columns

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EN
Abstracts
EN
Retention parameters of psychotropic drug
standards were determined on different columns,
i.e., Octadecyl silica, Phenyl, Phenyl-Hexyl, Polar
Reverse Phase, Pentafluorophenyl, and Cyanopropyl
using aqueous eluent systems containing methanol or
acetonitrile as organic modifiers, acetate buffer at pH 3.5
and addition of silanol blocker − diethylamine (DEA). The retention, separation selectivity, and sequence of
elution were different when using eluents containing various
organic modifiers. The significant differences were observed
in retention parameters with a change of the used stationary
phase. The various properties of stationary phases resulted
in differences in analyte retention, peaks shape, systems
efficiency and separation selectivity. The best shape of
peaks were on Cyanopropyl (CN) column and the highest
efficiency for most investigated psychotropic drugs were
obtained on Phenyl-Hexyl and Polar RP columns.
EN
Publisher

Journal
Year
Volume
13
Issue
1
Physical description
Dates
accepted
1 - 4 - 2015
received
12 - 12 - 2014
online
3 - 6 - 2015
Contributors
  • Department of Inorganic Chemistry Medical University
    of Lublin,Chodźki 4a, 20-093 Lublin, Poland
  • Department of Inorganic Chemistry Medical University
    of Lublin,Chodźki 4a, 20-093 Lublin, Poland
author
  • Department of Inorganic Chemistry Medical University
    of Lublin,Chodźki 4a, 20-093 Lublin, Poland
  • Department of Inorganic Chemistry Medical University
    of Lublin,Chodźki 4a, 20-093 Lublin, Poland
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_chem-2015-0106
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