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2015 | 13 | 1 |

Article title

Centaurea cyanus L. Polysaccharides and
Polyphenols Cooperation in Achieving Strong
Rat Gastric Ulcer Protection


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This work was aimed at testing gastroprotective
effects of Centaurea cyanus L. (herba) polysaccharides
(P) and polyphenols (A) fractions on stress-induced rat
ulcer model. Studies evaluating acute toxicity in rats
and antioxidant (chemiluminescence method) and
antimicrobial (on Staphylococcus aureus ATCC6538
and Escherichia coli ATCC8739 strains) activities of Centaurea cyanus L. (herba) product, which combined
polysaccharides and polyphenols fractions (PA), have also
been done. Accordingly, in vivo pharmacological studies
revealed high influence of PA product (500 mg kg-1 of body
weight) on deep, moderate and superficial gastric mucosal
lesions, greater than that of chemical reference, Ranitidine.
P product was proven more effective than Ranitidine in
opposing the emergence of deep necrotic lesions only,
suggesting the ability of polysaccharides compounds to
consolidate gastric mucous layer as well as their certain
tendency for cooperation with polyphenols fractions.
The acute toxicity study indicated the lack of toxicity of
PA product and maximum tolerated doses greater than
1875 mg kg-1 of body weight. PA product provided augmented
scavenger activity and week antimicrobial activity on Staphylococcus aureus ATCC6538 and Escherichia coli ATCC8739 strains, resulting in better opportunities for
valorisation of the aerial part of Centaurea cyanus L.
species in order to obtain new and effective natural








Physical description


1 - 3 - 2015
17 - 12 - 2014
26 - 5 - 2015


  • National Institute for Chemical-
    Pharmaceutical Research and Development (ICCF), Vitan 112,
    Sector 3, Bucharest, Romania
  • National Institute for Chemical-
    Pharmaceutical Research and Development (ICCF), Vitan 112,
    Sector 3, Bucharest, Romania
  • National Institute for Chemical-
    Pharmaceutical Research and Development (ICCF), Vitan 112,
    Sector 3, Bucharest, Romania
  • OVIDIUS University – Constanta,
    Mamaia 124, Constanta, Romania
  • OVIDIUS University – Constanta,
    Mamaia 124, Constanta, Romania
  • Academy of Romanian Scientists, Splaiul
    Independentei 54, Bucharest, Romania


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