Non-thermal plasma treatment induces MAPK signaling in human monocytes

• Authors: Lena Bundscherer , Stefanie Nagel , Sybille Hasse , Helena Tresp , Kristian Wende , Reinhard Walther , Stephan Reuter , Klaus-Dieter Weltmann , Kai Masur , Ulrike Lindequist
• Languages of publication: EN

Abstracts

EN

Keywords

EN

human monocytes ; MAPK signaling ; non-thermal plasma ; plasma medicine ; wound healing

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2015
• Volume: 13
• Issue: 1

Dates

accepted

24 - 6 - 2014

online

30 - 12 - 2014

received

7 - 1 - 2014

Contributors

author

Lena Bundscherer

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Stefanie Nagel

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Sybille Hasse

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Helena Tresp

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Kristian Wende

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Reinhard Walther

• Institute for Medical Biochemistry and Molecular
  Biology, University of Greifswald, Ferdinand-Sauerbruch-Straße /
  Klinikum DZ 7, 17489 Greifswald, Germany

author

Stephan Reuter

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Klaus-Dieter Weltmann

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Kai Masur

• Leibniz Institute
  for Plasma Science and Technology (INP Greifswald e.V.), Felix-
  Hausdorff-Str. 2, 17489 Greifswald, Germany

author

Ulrike Lindequist

• Institute of Pharmacy, Department of
  Pharmaceutical Biology, University of Greifswald, Friedrich-Ludwig-
  Jahn-Str. 17, 17489 Greifswald, Germany

References

• [1] Heinlin J., Isbary G., Stolz W., Morfill G., Landthaler M.,Shimizu T., et al., Plasma applications in medicine with a specialfocus on dermatology, J. Eur. Acad. Dermatol. Venereol., 2011,25, 1-11[Crossref]
• [2] Weltmann K. D., Polak M., Masur K., von Woedtke T., Winter J.,Reuter S., Plasma processes and plasma sources in medicine,Contrib. Plasma Phys., 2012, 52, 644-654
• [3] Koban I., Holtfreter B., Hubner N. O., Matthes R., Sietmann R.,Kindel E., et al., Antimicrobial efficacy of non-thermal plasma incomparison to chlorhexidine against dental biofilms on titaniumdiscs in vitro - proof of principle experiment, J. Clin. Periodontol.,2011, 38, 956-65[WoS]
• [4] Oehmigen K., Winter J., Hahnel M., Wilke C., Brandenburg R.,Weltmann K. D., et al., Estimation of possible mechanisms ofescherichia coli inactivation by plasma treated sodium chloridesolution, Plasma Process. Polym., 2011, 8, 904-913[Crossref][WoS]
• [5] Polak M., Winter J., Schnabel U., Ehlbeck J., Weltmann K. D.,Innovative plasma generation in flexible biopsy channels forinner-tube decontamination and medical applications, PlasmaProcess. Polym., 2012, 9, 67-76[Crossref][WoS]
• [6] Fricke K., Koban I., Tresp H., Jablonowski L., Schroder K.,Kramer A., et al., Atmospheric pressure plasma: A highperformancetool for the efficient removal of biofilms, PLoS ONE,2012, 7, e42539
• [7] Isbary G., Morfill G., Schmidt H. U., Georgi M., Ramrath K.,Heinlin J., et al., A first prospective randomized controlled trialto decrease bacterial load using cold atmospheric argon plasmaon chronic wounds in patients, Br. J. Dermatol., 2010, 163, 78-82[WoS]
• [8] Kalghatgi S., Friedman G., Fridman A., Clyne A. M., Endothelialcell proliferation is enhanced by low dose non-thermal plasmathrough fibroblast growth factor-2 release, Ann. Biomed. Eng.,2010, 38, 748-57[WoS]
• [9] Barton A., Wende K., Bundscherer L., Hasse S., Schmidt A.,Bekeschus S., et al., Non-thermal plasma increases expressionof wound healing related genes in a keratinocyte cell line,Plasma Med., 2013, 3, 125-136[Crossref]
• [10] Greaves N. S., Ashcroft K. J., Baguneid M., Bayat A., Currentunderstanding of molecular and cellular mechanisms infibroplasia and angiogenesis during acute wound healing, J.Dermatol. Sci., 2013, 72, 206-217[WoS]
• [11] Park J. E., Barbul A., Understanding the role of immuneregulation in wound healing, Am. J. Surg., 2004, 187, 11S-16S
• [12] Mahdavian Delavary B., van der Veer W. M., van Egmond M.,Niessen F. B., Beelen R. H., Macrophages in skin injury andrepair, Immunobiology, 2011, 216, 753-62
• [13] Reinke J. M., Sorg H., Wound repair and regeneration, Eur. Surg.Res., 2012, 49, 35-43[WoS][Crossref]
• [14] Enoch S., Leaper D. J., Basic science of wound healing, Surgery(Oxford), 2005, 23, 37-42.
• [15] Wang X., Studzinski G. P.,Activation of extracellular signal-regulated kinases (ERKs)defines the first phase of 1,25-dihydroxyvitamin D3-induceddifferentiation of HL60 cells, J. Cell Biochem., 2001, 80, 471-82
• [15] Himes S. R., Sester D. P., Ravasi T., Cronau S. L., Sasmono T.,Hume D. A., The JNK are important for development and survivalof macrophages, J. Immunol., 2006, 176, 2219-28
• [16] Wang Y., Zeigler M. M., Lam G. K., Hunter M. G., Eubank T. D.,Khramtsov V. V., et al., The role of the NADPH oxidase complex,p38 MAPK, and Akt in regulating human monocyte/macrophagesurvival, Am. J. Respir. Cell Mol. Biol., 2007, 36, 68-77
• [17] Geest C. R., Coffer P. J., MAPK signaling pathways in theregulation of hematopoiesis, J. Leukoc. Biol., 2009, 86, 237-50[WoS]
• [18] Schaeffer H. J., Weber M. J., Mitogen-activated protein kinases:Specific messages from ubiquitous messengers, Mol. Cell Biol.,1999, 19, 2435-44[Crossref]
• [19] Avisetti D. R., Babu K. S., Kalivendi S. V., Activation of p38/JNKpathway is responsible for embelin induced apoptosis in lungcancer cells: transitional role of reactive oxygen species, PLoSONE, 2014, 9, e87050
• [20] Metelmann H.-R., Vu T. T., Do H. T., Le T. N. B., Hoang T. H. A.,Phi T. T. T., et al., Scar formation of laser skin lesions after coldatmospheric pressure plasma (CAP) treatment: A clinical longterm observation, Clin. Plasma Med., 2013, 1, 30-35
• [21] Kramer A., Lademann J., Bender C., Sckell A., Hartmann B.,Münch S., et al., Suitability of tissue tolerable plasmas (TTP) forthe management of chronic wounds, Clin. Plasma Med., 2013,1, 11-18
• [22] Bundscherer L., Wende K., Ottmüller K., Barton A., Schmidt A.,Bekeschus S., et al., Impact of non-thermal plasma treatmenton MAPK signaling pathways of human immune cell lines,Immunobiology, 2013, 218, 1248– 1255[WoS]
• [23] Weltmann K. D., Kindel E., Brandenburg R., Meyer C., BussiahnR., Wilke C., et al., Atmospheric pressure plasma jet for medicaltherapy: Plasma parameters and risk estimation, Contrib.Plasma Phys., 2009, 49, 631-640[WoS]
• [24] Winter J., Wende K., Masur K., Iseni S., Dünnbier M., Hammer M.U., et al., Feed gas humidity: A hidden parameter affects coldatmospheric pressure plasma jet and plasma-treated humanskin cells, J. Phys. D.: Appl. Phys. , 2013, 46, 1-11
• [25] Xu K., Yu F. S., Impaired epithelial wound healing and EGFRsignaling pathways in the corneas of diabetic rats, Invest.Ophthalmol. Vis. Sci., 2011, 52, 3301-8[WoS]
• [26] Liu M. K., Herrera-Velit P., Brownsey R. W., Reiner N. E., CD14-dependent activation of protein kinase C and mitogen-activatedprotein kinases (p42 and p44) in human monocytes treated withbacterial lipopolysaccharide, J. Immunol., 1994, 153, 2642-52
• [27] Bhatt N. Y., Kelley T. W., Khramtsov V. V., Wang Y., Lam G. K.,Clanton T. L., et al., Macrophage-colony-stimulating factorinducedactivation of extracellular-regulated kinase involvesphosphatidylinositol 3-kinase and reactive oxygen speciesin human monocytes, J. Immunol., 2002, 169, 6427-34
• [28] Reuter S., Tresp H., Wende K., Hammer M. U., Winter J., MasurK., et al., From RONS to ROS: Tailoring plasma jet treatment ofskin cells, IEEE Transact. Plasma Sci., 2012, 40, 2986–2993
• [29] Torres M., Forman H. J., Redox signaling and the MAP kinasepathways, Biofactors, 2003, 17, 287-96[Crossref]
• [30] Ma R. N., Feng H. Q., Liang Y. D., Zhang Q., Tian Y., Su B.,et al., An atmospheric-pressure cold plasma leads to apoptosisin Saccharomyces cerevisiae by accumulating intracellularreactive oxygen species and calcium, J. Phys. D.: Appl. Phys.,2013, 46, [WoS]
• [32] Heidenreich S., Schmidt M., August C., ullen P.,Rademaekers A., Pauels H. G., Regulation of human monocyteapoptosis by the CD14 molecule, J. Immunol., 1997, 159, 3178-88
• [31] Cerella C., Coppola S., Maresca V., De Nicola M., Radogna F.,Ghibelli L., Multiple mechanisms for hydrogen peroxide-inducedapoptosis, Ann. N. Y. Acad. Sci., 2009, 1171, 559-63
• [32] Matsukawa J., Matsuzawa A., Takeda K., Ichijo H., The ASK1-MAPkinase cascades in mammalian stress response, J. Biochem.,2004, 136, 261-5.
• [33] Bundscherer L., Bekeschus S., Tresp H., Hasse S., Reuter S.,Weltmann K. D., et al., Viability of human blood leucocytescompared with their respective cell lines after plasma treatment,Plasma Med., 2013, 3, 71-80[Crossref]
• [34] Parihar A., Eubank T. D., Doseff A. I., Monocytes and macrophagesregulate immunity through dynamic networks of survival andcell death, J. Innate Immun., 2010, 2, 204-15[Crossref][WoS]
• [35] Barton A., Wende K., Bundscherer L., Weltmann K. D., LindequistU., Masur K., Non-Thermal Atmospheric Pressure PlasmaTreatment of Human Cells: The Effect of Ambient Conditions,Proceedings of 21st International Symposium on PlasmaChemistry (4-9 August 2013, Cairns, Australia), 2013
• [36] Tanigawa T., Kanazawa S., Ichibori R., Fujiwara T., Magome T.,Shingaki K., et al., (+)-Catechin protects dermal fibroblastsagainst oxidative stress-induced apoptosis, BMC Complement.Altern. Med., 2014, 14, 133[Crossref][WoS]
• [37] Tresp H., Hammer M. U., Winter J., Weltmann K. D., Reuter S.,Quantitative detection of plasma-generated radicals in liquidsby electron paramagnetic resonance spectroscopy, J. Phys. D.:Appl. Phys. , 2013, 46, 435401[WoS]
• [38] Tresp H., Hammer M. U., Weltmann K. D., Reuter S., Plasmagenerated reactive species in biologically relevant solutions,Plasma Med., 2013, 3, 45-55

Identifiers

DOI

10.1515/chem-2015-0071