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Article title

Cellular metabolism and lysosomal mTOR


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Over the last few years extensive studies have
linked the activity of mTORC1 to lysosomal function. These
observations propose an intriguing integration of cellular
catabolism, sustained by lysosomes, with anabolic
processes, largely controlled by mTORC1. Interestingly,
lysosomal function directly affects mTORC1 activity and
is regulated by ZKSCAN3 and TFEB, two transcription
factors and substrates of mTORC1. Thus, the lysosomal
mTOR signaling complex represents a hub of cellular
energy metabolism, and its dysregulation may lead to a
number of human diseases. Here, we discuss the recent
developments and highlight the open questions in this
growing field.








Physical description


24 - 11 - 2014
29 - 12 - 2014
30 - 1 - 2015


  • Federated Department
    of Biological Sciences, Rutgers University/New Jersey Institute of
    Technology, Newark, NJ 07102
  • Federated Department
    of Biological Sciences, Rutgers University/New Jersey Institute of
    Technology, Newark, NJ 07102
  • Federated Department
    of Biological Sciences, Rutgers University/New Jersey Institute of
    Technology, Newark, NJ 07102


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