Cellular metabolism and lysosomal mTOR
signaling

• Authors: Israel C. Nnah , Khoosheh Khayati , Radek Dobrowolski
• Languages of publication: EN

Abstracts

EN

Over the last few years extensive studies have
linked the activity of mTORC1 to lysosomal function. These
observations propose an intriguing integration of cellular
catabolism, sustained by lysosomes, with anabolic
processes, largely controlled by mTORC1. Interestingly,
lysosomal function directly affects mTORC1 activity and
is regulated by ZKSCAN3 and TFEB, two transcription
factors and substrates of mTORC1. Thus, the lysosomal
mTOR signaling complex represents a hub of cellular
energy metabolism, and its dysregulation may lead to a
number of human diseases. Here, we discuss the recent
developments and highlight the open questions in this
growing field.

Keywords

EN

Lysosomes; mTORC1; autophagy; endocytosis; TFEB; ZKSCAN3

• Publisher: De Gruyter Open
• Journal: Cell death in therapy
• Year: 2014
• Volume: 1
• Issue: 1

Dates

received

24 - 11 - 2014

accepted

29 - 12 - 2014

online

30 - 1 - 2015

Contributors

author

Israel C. Nnah

• Federated Department
  of Biological Sciences, Rutgers University/New Jersey Institute of
  Technology, Newark, NJ 07102

author

Khoosheh Khayati

• Federated Department
  of Biological Sciences, Rutgers University/New Jersey Institute of
  Technology, Newark, NJ 07102

author

Radek Dobrowolski

• Federated Department
  of Biological Sciences, Rutgers University/New Jersey Institute of
  Technology, Newark, NJ 07102

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Identifiers

DOI

10.1515/cdth-2015-0001