Four endophytic fungi isolated from the
marine red alga Bostrychia radicans identified as
Botryosphaeria sp. CBMAI 1197, Eutypella sp. CBMAI
1196, Hidropisphaera sp. CBMAI 1194 and Xylaria sp.
CBMAI 1195 catalyzed the asymmetric bioreduction of
fluoroacetophenone derivatives 1-3 to the corresponding
fluorophenylalcohols 1a-3a. In the reduction reactions
of 2,2,2-trifluoro-1-phenylethanone 1, all the marine
fungi produced exclusively the (S)-2,2,2-trifluoro-
1-phenylethanol 1a with > 99% ee. The fungus
Botryosphaeria sp. CBMAI 1197 exhibited the best
enzymatic potential, leading to the highest conversion
values (up to > 99%). The biocatalyst Botryosphaeria sp.
CBMAI 1197 also presented active enzymes in reactions
with the substrates 1-(2-(trifluoromethyl)phenyl)
ethanone (2) and 1-(2,4,5-trifluorophenyl)ethanone (3),
producing the respective chiral alcohols S-2a and R-3a
with > 99% ee. Additionally, the fungus Hidropisphaera
sp. CBMAI 1194 yielded 100% of conversion of the ketone
3 to the corresponding S-alcohol 3a, with 53% ee.