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Number of results

Journal

2016 | 3 | 1 |

Article title

Differences in basal DNA damage in blood cells
from men and women

Content

Title variants

Languages of publication

EN

Abstracts

EN
We have recently shown that inhabitants of
two polluted areas in Kosovo display more DNA damage
(strand breaks in blood cell DNA) than do residents of
a cleaner area. Here, we present additional analyses of
these data and discuss additional data sets from Kosovo.
Based on our data as well as the available data from
other authors, age and sex-related differences in DNA
damage or in susceptibility to DNA-damaging agents in
the environment should be carefully considered when
designing biomonitoring studies and when carrying out
statistical analysis of the data.

Publisher

Journal

Year

Volume

3

Issue

1

Physical description

Dates

online
17 - 3 - 2016
accepted
22 - 2 - 2016
received
4 - 2 - 2016

Contributors

  • Department of Biology, University
    of Prishtina, Xhorxh Bush, n.n.,10000, Prishtina, Kosovo
  • Department of Nutrition, Institute of Basic
    Medical Sciences, University of Oslo, PB 1046 Blindern, 0316 Oslo,
    Norway.
  • Faculty of Medicine, University of Prishtina,
    Xhorxh Bush Street, n.n.,10000, Prishtina, Kosovo
  • Department of Biology, University
    of Prishtina, Xhorxh Bush, n.n.,10000, Prishtina, Kosovo
  • Department of Biology, University
    of Prishtina, Xhorxh Bush, n.n.,10000, Prishtina, Kosovo
  • Department of Cell Biology, University
    of Salzburg, Hellbrunnerstr. 34, A-5020 Salzburg, Austria
author
  • Department of Cell Biology, University
    of Salzburg, Hellbrunnerstr. 34, A-5020 Salzburg, Austria

References

  • [1] Dusinska M, Collins AR: The comet assay in humanbiomonitoring: gene–environment interactions. Mutagenesis.2008; 23(3): 191-205.[WoS][Crossref]
  • [2] Collins AR, Azqueta A: Single-cell gel electrophoresis combinedwith lesion-specific enzymes to measure oxidative damage to DNA. In P.M.Conn (ed.), Laboratory Methods in Cell Biology,2012, pp. 69-92, Elsevier Inc.[WoS]
  • [3] Azqueta A, Collins AR: The essential comet assay: a comprehensiveguide to measuring DNA damage and repair. ArchToxicol. 2013; 87(6): 949-968.[WoS]
  • [4] Collins A, Koppen G, Valdiglesias V, Dusinska M, KruszewskiM, Møller P, Rojas E, Dhawan A, Benzie I, Coskun E, MorettiM, Speit G, Bonassi S, ComNet project: The comet assay as a tool for human biomonitoring studies: the ComNet project,Mutat Res Rev Mutat Res. 2014; 759: 27-39.[WoS]
  • [5] Møller P, Knudsen LE, Loft S, Wallin H: The Comet Assay asa Rapid Test in Biomonitoring Occupational Exposure toDNA-damaging Agents and Effect of Confounding Factors.Cancer Epidemiol Biomarkers Prev. 2000; 9 (10): 1005-1015.
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  • [7] Alija AJ, Asllani F, Bajraktari ID, Collins AR, Dreshaj S, BresgenN, Eck PM: Atmospheric pollution in Kosovo is associatedwith increased DNA damage in the human population.Biomonitoring. 2015; 2 (1): 35-41.
  • [8] Møller P: Assessment of reference values for DNA damagedetected by the comet assay in human blood cell DNA. MutatRes. 2006; 612 (2): 84-104.
  • [9] Kruszewski M, Wojewódzka M, Iwanen̄ko T, Collins AR, SzumielI: Application of the comet assay for monitoring DNA damagein workers exposed to chronic low-dose irradiation: II. Basedamage. Mutat Res. 1998; 416 (1-2): 37–57.
  • [10] Pérez-Cadahía B, Méndez J, Pásaro E, Lafuente A, CabaleiroT, Laffon B: Biomonitoring of Human Exposure to Prestige Oil: Effects on DNA and Endocrine Parameters. Environ HealthInsights. 2008; 2: 83–92.
  • [11] Betti C, Davini T, Giannessi L, Loprieno N, Barale R: Microgelelectrophoresis assay (comet test) and SCE analysis in humanlymphocytes from 100 normal subjects. Mutat Res. 1994; 307(1): 323-333.
  • [12] Wojewódzka M, Kruszewski M, Iwaneñko T, Collins AR, SzumielI: Application of the comet assay for monitoring DNA damagein workers exposed to chronic low-dose irradiation. I. Strandbreakage. Mutat Res. 1998; 416 (1-2): 21-35.
  • [13] Bajpayee M, Dhawan A, Parmar P, Pandey AK, Mathur N,Seth PK: Gender-related differences in basal DNA damage inlymphocytes of a healthy Indian population using the alkalineComet assay. Mutat Res. 2002; 520 (1-2): 83–91.
  • [14] Garaj-Vrhovac V, Kopjar N: The alkaline Comet assay asbiomarker in assessment of DNA damage in medical personneloccupationally exposed to ionizing radiation. Mutagenesis.2003; 18 (3): 265–271.[Crossref]
  • [15] Zhu CQ, Lam TH, Jiang CQ, Wei BX, Lou X, Liu WW, Lao XQ, ChenYH: Lymphocyte DNA damage in cigarette factory workers measured by the Comet assay, Mutat Res., 1999; 444 (1) 1-6.

Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_bimo-2016-0001
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