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2015 | 1 | 1 |

Article title

Novel antibacterial bioactive glass nanocomposite
functionalized with tetracycline hydrochloride

Content

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EN

Abstracts

EN
To prevent the high frequency of wound infections,
anti-bacterial agents can be loaded onto composites.
In the present study, the antibiotic tetracycline hydrochloride
(TC)was incorporated, for the first time, in collagen
type I membranes coated with nano-sized SiO2-CaOP2O5
bioactive glass (n-BG) obtained by a sol-gel chemical
route. Collagen membranes coated with n-BG were immersed
in simulated body fluid (SBF) containing 0.25, 0.75 or
1.25 mg mL−1 of TC for 48 h at 37∘C following a coprecipitation
method. The antibiotic was released in distilledwater
at 37∘C for up to 72 h. The antibacterial activity
of the composites was evaluated in vitro by the inhibition
zone test and plate count method. Two different Staphylococcus
aureus strains, S. aureus ATCC29213 and S. aureus
ATCC25923, were exposed to the biomaterials. The results
showed that the incorporation but not the release of TC
was dependent on the initial concentration of TC in SBF.
The biomaterials inhibited S. aureus growth, although the
efficacy was similar for all the concentrations. The results
allow us to conclude that the new composite could have
potential in the prevention of wound infections.

Publisher

Year

Volume

1

Issue

1

Physical description

Dates

accepted
2 - 9 - 2015
online
21 - 10 - 2015
received
27 - 8 - 2015

Contributors

  • Grupo Interdisciplinario
    en Materiales-Universidad Católica de Salta (IESIINGUCASAL),
    Instituto de Tecnologías y Ciencias de Ingeniería-
    Universidad Buenos Aires-Consejo Nacional de Investigaciones
    Científicas y Técnicas (INTECIN UBA-CONICET), Campo Castañares
    s/n, Salta, Argentina
author
  • 3B’s Research Group-Biomaterials,
    Biodegradables and Biomimetics, University of Minho, Headquarters
    of the European Institute of Excellence on Tissue Engineering
    and Regenerative Medicine, P-4806-909 Taipas, Guimarães, Portugal;
    ICVS/3B’s Associate Laboratory, Braga/Guimarães, Portugal
  • Instituto de Investigaciones para la Industria
    Química - Consejo Nacional de Investigaciones Científicas y Técnicas (INIQUI - CONICET), Universidad Nacional de Salta (UNSa), Av.
    Bolivia 5150, Salta, Argentina
author
  • 3B’s Research Group-Biomaterials,
    Biodegradables and Biomimetics, University of Minho, Headquarters
    of the European Institute of Excellence on Tissue Engineering
    and Regenerative Medicine, P-4806-909 Taipas, Guimarães, Portugal;
    ICVS/3B’s Associate Laboratory, Braga/Guimarães, Portugal
  • Grupo Interdisciplinario
    en Materiales-Universidad Católica de Salta (IESIINGUCASAL),
    Instituto de Tecnologías y Ciencias de Ingeniería-
    Universidad Buenos Aires-Consejo Nacional de Investigaciones
    Científicas y Técnicas (INTECIN UBA-CONICET), Campo Castañares
    s/n, Salta, Argentina

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_bglass-2015-0012
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