The 45S5 Bioglassr and its sintered bioactive
glass-ceramic (BGC) have been widely investigated as
bone implants, mainly for its ability to bond to hard tissues.
However, high temperature treatment is not enough
to improve its poor mechanical properties, but compromise
its biologically relevant performances. The innovative
BGC compositions based on the thermally treated 45S5
Bioglassr were developed by decreasing the P2O5 quantity
and adding B2O3 (0-6%) into the Na2O–2CaO–3SiO2-
based bioactive glasses (BG). The thermally treated BGCs
were fully characterized from the microstructural and mechanical
points of view and compared to each other. Their
bioactivity and bio-dissolutionwere established by means
of in vitro soaking tests. The new B2O3-added 45S5 BG
analogues, named NCS-xB, can be transformed to crystalline
phase (Na2Ca2Si3O9)-based BGCs of high compactness
and bioactivity at a relatively low temperature heat
treatment (≤ 900ºC), since their bioactivity is preserved.
Our experimental results suggest that the new 45S5 BGC
analogues with optimized composition exhibit improved
micro- structural and mechanical properties, and are beneficial
for making specific products such as porous scaffolds
or composites for bone defect repair.