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2015 | 1 | 1 |

Article title

"Imageable" Zinc-Silicate Glass Microspheres For
Transarterial Embolization: A Renal Artery
Embolization Study.


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Intrinsically radiopaque (imageable) microspheres
for transarterial embolization (TAE) are required
to enable real-time intraprocedural feedback and definition
of spatial distribution patterns of embolic materials
in target tissues. This pilot study evaluates acute and
sub-chronic safety and efficacy of imageable zinc-silicate
(Zn-Si) glass microspheres in a swine renal artery embolization
(RAE) model. Eight swine were divided into
two cohorts. Clinical determinants of embolization effectiveness,
including imageability, deliverability and temporal/
spatial distribution of microspheres in target tissues
were assessed. Subsequently, cohort I and II were used to
evaluate the acute and subchronic host response against
the Zn-Si microspheres versus a clinical control. The developed
microspheres provide for direct intraprocedural
feedback using standard diagnostic imaging techniques.
Fluoroscopy correlated with ex-vivo high-resolution radiography,
CT and micro-CT, demonstrating high imageability,
excellent spatial distribution and packing of the Zn-
Si microspheres. At follow-up, infarction of the embolized
kidneys was noted without any major adverse tissue reaction.
Mild recanalization was observed microscopically
for both experimental and control microspheres. Zn-Si microspheres
permit the definition of spatial distribution in
a target tissue, consequently permitting the optimization,
personalization and improvement of TAE techniques.







Physical description


26 - 8 - 2015
8 - 6 - 2015
8 - 6 - 2015



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