Influence of textural properties on
biomineralization behavior of mesoporous
bioactive glasses

• Authors: Anil Kumar , Sevi Murugavel
• Languages of publication: EN

Abstracts

EN

A new method of calcination for the sol-gel derived
bioactive glass sample has been developed to produce
superior textural and bioactive properties. Based
on this method, mesoporous 67.4 SiO2-25 Na2O-5 CaO-
2.6 P2O5 (mol.%) bioactive glasses (MBGs) have been synthesized
through acid assisted sol-gel technique followed
by evaporation induced self-assembly (EISA) process,
commonly used for obtaining bioactive glasses. Moreover,
the use of microwave irradiation has been compared with
that of conventional heat treatment for a particular quaternary
composition,which has allowed the homogeneous
spatial distribution of heat and to obtain smaller, uniform
pore sizes with high surface area. The distinctions
between the two methods of calcination have been observed
in the structural, morphology and textural characteristics.
The superior textural characteristics have allowed
the rapid dissolution of MBGs followed by development
of nanocrystalline hydroxycarbonate apatite (HCA)
layer. In vitro bioactive analyses on both MBGs have revealed
a rapid formation HCA layer with distinct behavior
on the biomineralization process. The difference in the behavior
of biomineralization process is attributed to the kinetics
of supersaturation of the biological medium.

Keywords

EN

Bioactive glass; Microwave irradiation; Bioactivity; EISA; SBF

• Publisher: De Gruyter Open
• Journal: Biomedical glasses
• Year: 2015
• Volume: 1
• Issue: 1

Dates

accepted

12 - 4 - 2015

online

16 - 7 - 2015

received

8 - 1 - 2015

Contributors

author

Anil Kumar

• Department of Physics and Astrophysics, University of
  Delhi, Delhi-110007, India

author

Sevi Murugavel

• Department of Physics and Astrophysics, University of
  Delhi, Delhi-110007, India

References

• [1] Jones J.R., Gentleman E., Polak J., Bioactive glass scaffolds forbone regeneration, Elements, 2007, 3, 393-399[Crossref][WoS]
• [2] Albrektsson T., Johansson C., Osteoinduction, osteoconductionand osseointegration, Eur Spine J., 2001, 10, S96-S101
• [3] Chen Q.Z., Thouas G.A., Fabrication and characterization of solgelderived 45S5 bioglass ceramics scaffolds, Acta. Biomater.,2011, 7, 3616-3626[Crossref]
• [4] Chen Q.Z., Xu J.L., Yu L.G., Fang X.Y., Khor K.A., Spark plasmasintering of sol-gel derived 45S5 bioglass ceramics: mechanicalproperties and biocompatibility evaluation, Mater. Sci. Eng. C,2012, 32, 494-502[Crossref]
• [5] Pirayesh H., Nychka J.A., Sol-gel synthesis of bioactive glassceramics45S5 and its in vitro dissolution and mineralizationbehavior, J. Am. Ceram. Soc., 2013, 96, 1643-1650[WoS][Crossref]
• [6] Wu C., Luo Y., Cuniberti G., Xia Y., Gelinsky M., Three dimensionalprinting of hierarchical and tough mesoporous bioactiveglass scaffolds with controllable pore architecture, excellentmechanical strength and mineralization ability, Acta. Biomater.,2011, 7, 2644-2650[WoS][Crossref]
• [7] Fu Q., Rahaman M.N., Bal B.S., Brown R.F., Day D.E., Mechanicaland in vitro performance of 13-93 bioactive glass scaffolds preparedby a polymer foam replication technique, Acta. Biomater.,2008, 4, 1854-1864[Crossref][WoS]
• [8] Pena J., Roman J., Cabanas M.V., Vallet-Regi M., An alternativetechnique to shape Scaffoldswith hierarchical porosity at physiologicaltemperature, Acta. Biomater., 2010, 6,1288-1296[WoS][Crossref]
• [9] Mallick K.K., Freeze casting of porous bioactive glass and bioceramics,J. Am. Chem. Soc., 2009, 92 [S1], S85-S94
• [10] Yan X., Huang X., Yu C., Deng H., Wang Y., Zhong Z., Qiao S.,Lu G., Zhao D., The in-vitro bioactivity of mesoporous bioactiveglasses, Biomater., 2006, 27, 3396-3403[Crossref]
• [11] Xia W., Chang J., Well-ordered mesoporous bioactive glasses(MBG): a promising bioactive drug delivery system, J. Cont. Rel.,2006, 110, 522-530
• [12] Yun H.S., Kim S.E., Hyun Y.T., Heo S.J., Shin J.W., Hierarchicallymesoporous–macroporous bioactive glasses scaffolds for bonetissue regeneration, J. Biomed. Mater. Res. B: Appl. Biomater.,2008, 87B, 374-380[Crossref]
• [13] Yun H.S., Kim S.E., Hyeon Y.T., Design and preparation of bioactiveglasses with hierarchical pore networks, Chem. Comm.,2007, 21, 2139-2141[Crossref]
• [14] Li X., Wang X., Chen H., Jiang P., Dong X., Si J., Hierarchicallyporous bioactive glass scaffolds synthesized with a PUF andP123 contemplated approach, Chem. Mater., 2007, 19, 4322-4326[Crossref][WoS]
• [15] Zhu Y., Wu C., Ramaswamy Y., Kockrick E., Simon P., Kaskel S.,Zreiqat H., Preparation, characterization and in vitro bioactivityof mesoporous bioactive glasses (MBGs) scaffolds for bonetissue engineering, Micropor. Mesopor., 2008, 112, 494-503[Crossref]
• [16] Brinker C.J., Lu Y., Sellinger A., Fan H., Evaporation-induced selfassembly:nanostructures made easy, Adv. Mater., 1999, 11,579-585[Crossref]
• [17] Shih C.C., Chien C.S., Kung J.C., Chen J.C., Chang S.S., Lu P.S.,Shih C.J., Effect of surfactant concentration on characteristics ofmesoporous bioactive glass prepared by evaporation inducedself-assembly, Appl. Surf. Sci., 2013, 264, 105-110[WoS]
• [18] Li X., Shi J., Dong X., Zhang L., Zeng H., A mesoporous bioactiveglass/polycaprolactone composite scaffold and its bioactivitybehavior, J. Biomed. Mater. Res. A, 2008, 84A, 84-91[WoS]
• [19] Alcaide M., Portoles P., Noriega A.L., Arcos D., Vallet-Regi M.,Portoles M.T., Interaction of an ordered mesoporous bioactiveglass with osteoblasts, fibroblasts and lymphocytes, demonstratingits biocompatibility as a potential bone graft material,Acta. Biomater., 2010, 6, 892-899[Crossref][WoS]
• [20] Noriega A.L., Arcos D., Barba I.I., Sakamoto Y., Terasaki O.,Vallet-Regi M., Ordered mesoporous bioactive glasses for bonetissue regeneration, Chem. Mater., 2006, 18, 3137-3144[Crossref]
• [21] Yan X.X., Deng H.X., Huang X.H., Lu G.Q., Qiao S.Z., Zhao D.Y., YuC.Z., Mesoporous bioactive glasses I. synthesis and structuralcharacterization, J. Non-Cryst. Solids, 2005, 351, 3209-3217
• [22] Hoppe A., Guldel N.S., Boccaccini A.R., A review of the biologicalresponse to ionic dissolution products from bioactive glassesand glass-ceramics, Biomater., 2011, 32, 2757-2774[Crossref]
• [23] Vaid C., Murugavel S., Alkali oxide containing mesoporousbioactive glasses: synthesis, characterization and in vitrobioactivity, Mater. Sci. Eng C, 2013, 33, 959-968[Crossref][WoS]
• [24] Vaid C., Murugavel S., Kashayap R., Tandon R.P., Synthesis andin vitro bioactivity of surfactant templated mesoporous sodiumsilicate glasses, Micropor. Mesopor. Mater., 2012, 159, 17-23
• [25] Kokubo T., Takadama H., How useful is SBF in predicting in vivobone bioactivity?, Biomater., 2006, 27, 2907-2915[Crossref]
• [26] Aguiar H., Serra J., Gonzalez P., Leon B., Structural study of sol–gel silicate glasses by IR and Raman spectroscopies, J. Non-Cryst. Solids, 2009, 355, 475-480
• [27] Bhambhani M.R., Cutting P.A., Sing K.S.W., Turk D.H., Analysisof nitrogen adsorption isotherms on porous and nonporous silicasby the BET and as methods, J. Colloid Interface Sci., 1972,308, 109-117.
• [28] Horcajada P., Ramila A., Boulahya K., Gonzalez-Calbet J., Vallet-Regi M., Bioactivity in ordered mesoporous materials, SolidState Sci., 2004, 6, 1295-1300.[Crossref]
• [29] Du Min Q., Bian Z., Jiang H., Greenspan D.C., Burwell A.K., ZhongJ., Tai B.J., Clinical evaluation of a dentifrice containing calciumsodium phosphosilicate (novamin) for the treatment of dentinhypersensitivity, Am. J. Dent., 2008, 21, 210-214.
• [30] Weiner S., Dove P.M., An overview of biomineralization processesand the problem of the vital effect, Rev. Mineral.Geochem., 2003, 54, 1-29[Crossref]
• [31] Garcia A., Cicuendez M., Barba I.I., Arcos D., Vallet-Regi M.,Essential role of calcium phosphate heterogeneities in 2Dhexagonaland 3D-cubic SiO2-CaO-P2O5 mesoporous bioactiveglasses, Chem. Mater., 2009, 21, 5474-5484
• [32] Yan H., Zhang K., Blandford C.F., Francis L.F., Stein A., In vitrohydroxycarbonate apatite mineralization of CaO-SiO2 sol-gelglasses with a three-dimensionally orderedmacroporous structure,Chem. Mater., 2001, 13, 1374-1382[Crossref]
• [33] Salinas A.J.,Martin A.I., Vallet-Regi M., Bioactivity of three CaO–P2O5–SiO2 sol-gel glasses, J. Biomed. Mater. Res. A, 2002, 61,524-532 [Crossref]

Identifiers

DOI

10.1515/bglass-2015-0002