EN
Hydroamination of unsaturated carbon-carbon
bonds is a useful C-N bond forming reaction as it leads
to products (amines, imines, enamines) of high synthetic
value. While the hydroamination of terminal alkenes and
alkynes under metal catalysis has been widely developed,
the corresponding reactions with internal substrates
remain a challenge. Two recent studies by Buchwald and
by Dong which focus on enantioselective hydroamination
of internal alkenes and alkynes respectively are of
significant importance. [43,44] The results reported
broaden the scope of hydroamination as a useful C-N
bond forming process and allow acess to chiral amines
which are difficult to synthesize by other methods.