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Article title

Organocatalytic Enantioselective [3+2]
Cycloaddition of Azomethine Ylides and Acrolein

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EN
Abstracts
EN
The [3+2]-cycloaddition reaction between
acrolein and in situ generated acyclic azomethine ylides
promoted by a chiral secondary amine to generate C-3
unsubstituted pyrrolidines has been studied in detail.
Optimum conditions involve the use of the cheap and
readily available l-Proline as catalyst to afford the
pyrrolidine cycloadduct with complete diastereomeric
control and up to 80% enantiomeric control.
Publisher
Year
Volume
2
Issue
1
Physical description
Dates
received
19 - 1 - 2015
online
26 - 3 - 2015
accepted
9 - 2 - 2015
References
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  • [87] The cycloaddition adduct was found to epimerize at the formyl-containing stereocentre upon standing at r.t.
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_asorg-2015-0003
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