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Number of results
2015 | 2 | 1 |

Article title

Solvent-controlled diastereoselectivity in
tryptophan-catalyzed Mannich reactions

Content

Title variants

Languages of publication

EN

Abstracts

EN
Solvent effects in the L-tryptophan-catalyzed
Mannich reaction between hydroxyacetone and
glyoxylate imines have been examined. The use of a
DMSO/1-butanol (4:1 v/v) mixture as solvent at rt provided
the expected Mannich adducts in good yields, high
anti-diastereoselectivity (up to 10.3:1 anti/syn ratio) and
excellent enantioselectivities (up to >99.9% ee for the anti
isomer).

Publisher

Year

Volume

2

Issue

1

Physical description

Dates

online
12 - 6 - 2015
accepted
16 - 11 - 2014
received
28 - 10 - 2014

Contributors

  • Departament de Química Orgànica,
    Universitat de Barcelona, Facultat de Química, C. Martí i Franquès
    1-11, 08028-Barcelona, Catalonia, Spain
  • Departament de Química Orgànica,
    Universitat de Barcelona, Facultat de Química, C. Martí i Franquès
    1-11, 08028-Barcelona, Catalonia, Spain
author
  • Departament de Química Orgànica,
    Universitat de Barcelona, Facultat de Química, C. Martí i Franquès
    1-11, 08028-Barcelona, Catalonia, Spain

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_1515_asorg-2015-0001
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