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2015 | 2 | 1 |
Article title

Solvent-controlled diastereoselectivity in
tryptophan-catalyzed Mannich reactions

Content
Title variants
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EN
Abstracts
EN
Solvent effects in the L-tryptophan-catalyzed
Mannich reaction between hydroxyacetone and
glyoxylate imines have been examined. The use of a
DMSO/1-butanol (4:1 v/v) mixture as solvent at rt provided
the expected Mannich adducts in good yields, high
anti-diastereoselectivity (up to 10.3:1 anti/syn ratio) and
excellent enantioselectivities (up to >99.9% ee for the anti
isomer).
Publisher
Year
Volume
2
Issue
1
Physical description
Dates
online
12 - 6 - 2015
accepted
16 - 11 - 2014
received
28 - 10 - 2014
References
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_1515_asorg-2015-0001
Identifiers
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