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Association analysis of thyroglobulin gene variants with carcass and meat quality traits in beef cattle

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Gan G.-F., Zhang L.-P., Li J.-Y., Hou G.-Y., Li H.-D., Gao X., Ren H.-Y., Chen J.-B., Xu S.-Z.

Journal of Applied Genetics

2008

vol. 49

issue 3

251-255

Thyroid hormones play an important role in regulating the metabolism and can affect the homeostasis of fat deposition. The gene encoding thyroglobulin (TG), producing the precursor for thyroid hormones, has been proposed as a positional and functional candidate gene for a QTL with an effect on fat deposition. In the present study, we identified 6 novel SNPs at the 3? flanking region of the TG gene. The SNP marker association analysis indicated that the SNP markers G133C, G156A, C220T and A506C were significantly associated with marbling score (P<0.05, N=271). Animals with the new homozygote genotype had higher marbling scores than those with the other genotypes. Besides, the linkage disequilibrium analysis indicated that these 4 SNPs were completely linked (r2 = 1). Results of this study suggest that the TG-gene-specific SNP may be a useful marker for meat quality traits in future marker-assisted selection programmes in beef cattle.

Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)

100%

Zhang L.-P., Gan Q.-F., Zhang X.-H., Li H.-D., Hou G.-Y., Li Y.-J., Gao X., Ren H.-Y., Chen J. B., Xu S.-Z.

Journal of Applied Genetics

2009

vol. 50

issue 2

145-148

The aim of this study was to detect polymorphism in the bovine bone morphogenetic protein 15 (BMP15) gene. On the basis of PCR-SSCP and DNA sequencing, a 4-bp deletion was identified in the coding region of the gene. Sequence analysis revealed that the deletion altered the reading frame and introduced a stop codon at position 264. Eight breeds (Luxi, Qinchuan, Nanyang, Jinnan, Bohai Black, Menggolian, Holstein, and Simmental) were genotyped by PCR-SSCP. No cows homozygous for this mutation were observed in these breeds. Heterozygous cows were detected in Luxi, Qinchuan, Nanyang, Jinnan and Bohai Black cattle. Fecundity was not increased in heterozygous individuals.

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2 Journal of Applied Genetics

1 2009

1 2008

2 Gao X.

2 Hou G.-Y.

2 Li H.-D.

2 Ren H.-Y.

2 Xu S.-Z.

2 Zhang L.-P.

1 Chen J. B.

1 Chen J.-B.

1 Gan G.-F.

1 Gan Q.-F.

1 Li J.-Y.

1 Li Y.-J.

1 Zhang X.-H.

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Association analysis of thyroglobulin gene variants with carcass and meat quality traits in beef cattle

Detecting a deletion in the coding region of the bovine bone morphogenetic protein 15 gene (BMP15)